Dioxin-like PCBs and Endometriosis

Kaylon L Bruner-Tran, Kaylon L. Bruner‐Tran, Kevin G Osteen
Systems biology in reproductive medicine · 2010 · vol. 56(2) , pp. 132–146 · doi:10.3109/19396360903381023 · PMID:20377312 · PMC2867352 · W2070549294
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This review examines the limited data linking dioxin-like polychlorinated biphenyls to endometriosis, focusing on potential early life exposure effects.

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Abstract

A recent survey in the United States identified 287 different chemicals in human cord blood, demonstrating the significant exposure of women and their children to a wide array of environmental toxicants. While reducing contamination and exposure should be an international priority, it is equally appropriate to develop an understanding of the health consequences of increasing world-wide industrialization. Endometriosis, a disease of the female reproductive tract, has emerged as a disease potentially related to environmental exposures. While a number of population-based studies have suggested that a woman's exposure to dioxin-like polychlorinated biphenyls may affect her risk of developing this disease, other studies have failed to find such evidence. In the current manuscript, we will review the limited data regarding polychlorinated biphenyl congeners and endometriosis with a focus on dioxin-like toxicants. We will also discuss the potential importance of early life exposures to these toxicants on the subsequent development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Dioxins Endometriosis Environmental Pollutants Polychlorinated Biphenyls Adult Dioxins Endometriosis Endometrium Endometrium Environmental Exposure Environmental Pollutants Female Fetal Blood Fetal Blood Humans Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects United States

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