Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis

M Tsuchiya, Masaki Tsuchiya, Hiromasa Tsukino, Motoki Iwasaki, Hiroshi Sasaki, Tadao Tanaka, Takahiko Katoh, Donald G Patterson, Wayman E. Turner, Wayman Turner, Larry Needham, Larry L. Needham, Shoichiro Tsugane
Molecular human reproduction · 2007 · vol. 13(6) , pp. 399–404 · doi:10.1093/molehr/gam018 · PMID:17449539 · W2122887781
article OA: bronze CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that CYP1A1 and CYP1B1 gene polymorphisms may interact with serum organochlorine TEQ levels to modify the risk of advanced endometriosis in infertile Japanese women.

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Abstract

Exposure to dioxins and polychlorinated biphenyls (PCBs) has been suggested as a possible etiologic factor for endometriosis, but the association remains highly controversial. To assess whether cytochrome P450 (CYP) gene polymorphisms modulate the effect of dioxins and/or PCBs in endometriosis risk, we conducted a case-control study among infertile Japanese women. A total of 138 eligible women aged 20-45 were diagnosed laparoscopically and classified into three subgroups: control (no endometriosis), early endometriosis (stages I-II) and advanced endometriosis (stages III-IV). Neither CYP1A1 Ile462Val and CYP1B1 Leu432Val polymorphisms (genotypes with versus genotypes without the minor allele) nor serum dioxin and PCB toxic equivalency (TEQ) levels (low versus high) were independently associated with either early or advanced endometriosis risk. However, genotypes with the CYP1A1 462Val allele showed a statistically significant reduced risk of advanced endometriosis in combination with high serum dioxin TEQ levels (adjusted odds ratio = 0.13, 95% confidence interval: 0.02-0.76) (P for interaction = 0.08). Although no association was found between serum PCB TEQ level and advanced endometriosis in any stratum of CYP1B1 Leu432Val polymorphism, a statistically significant interaction was found (P for interaction = 0.05). CYP1A1 and CYP1B1 polymorphisms may modify the relation between environmental exposure to organochlorine and advanced endometriosis risk.

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Condition tags

endometriosis

MeSH descriptors

Cytochrome P-450 CYP1A1 Cytochrome P-450 Enzyme System Dioxins Endometriosis Polychlorinated Biphenyls Polymorphism, Genetic Adult Aryl Hydrocarbon Hydroxylases Case-Control Studies Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System Dioxins Dioxins Endometriosis Endometriosis Female Humans Middle Aged Polychlorinated Biphenyls

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