The genetics of endometriosis

Kennedy S, S Kennedy, Stephen Kennedy
European journal of obstetrics, gynecology, and reproductive biology · 1999 · vol. 82(2) , pp. 129–133 · doi:10.1016/s0301-2115(98)00213-9 · PMID:10206402 · W2147066445
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigates the genetic factors contributing to endometriosis, aiming to identify specific genes and pathways involved in the disease's development and progression.

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Abstract

There is mounting evidence that endometriosis is inherited as a complex trait, like diabetes or asthma. This implies there are environmental factors, such as dioxin, that are interacting with multiple genetic susceptibility loci to produce the phenotype. The Oxford Endometriosis Gene (OXEGENE) study, an international collaborative project, seeks to identify the susceptibility loci using linkage analysis; the aim then is to use positional cloning techniques to identify genes that predispose women to the disease. Analysis of the biochemical function of the gene products will lead to a better understanding of the pathophysiology and aetiology of endometriosis. New therapies may be designed based upon knowledge of the gene function and disease associated genetic markers may be used to identify women at high risk of developing the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Animals Dioxins Dioxins Endometriosis Female Genetic Linkage Genetic Predisposition to Disease Humans Macaca mulatta UTP-Hexose-1-Phosphate Uridylyltransferase UTP-Hexose-1-Phosphate Uridylyltransferase

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (52)

Cited by (50)

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europepmc
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