Common comorbid disorders in endometriosis patients

Emmanuel O Adewuyi
In: Queensland University of Technology · 2021 · doi:10.5204/thesis.eprints.212039 · W3196384463
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This study used genetic analyses to confirm comorbid associations between endometriosis and asthma, depression, and migraine, largely due to shared genetics, with potential causal links to depression and certain gastric conditions.

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This PhD project examined the genetic relationship between endometriosis and common comorbid disorders including asthma, depression, and migraine using statistical genetic approaches applied to world-leading genetic data. The findings confirmed comorbid associations between endometriosis and each of asthma, depression, and migraine, largely attributed to shared genetics and biological mechanisms, and causality assessment suggested a potential causal relationship between endometriosis and depression. Further analyses implicated causal links between endometriosis and depression and at least one abnormal gastric mucosal condition, specifically gastritis and gastroesophageal reflux disease. This paper is centrally about endometriosis — it focuses on endometriosis comorbidities (asthma, depression, migraine) and related causal genetic overlap.

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Abstract

This PhD project advances our understanding of the relationship between endometriosis and its common comorbid disorders with a focus on asthma, depression, and migraine. Appropriate sets of well-regarded statistical genetic approaches were utilised in the analysis of world-leading genetic data. Findings confirm a comorbid association between endometriosis and each of asthma, depression, and migraine, largely due to shared genetics and biological mechanisms. Causality assessment suggests a potential causal relationship between endometriosis and depression. Further analyses implicate causal links between each of endometriosis and depression and at least one abnormal condition of gastric mucosa—gastritis and gastroesophageal reflux disease.
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Common comorbid disorders in endometriosis patients Adewuyi, Emmanuel Olorunleke (2021) Common comorbid disorders in endometriosis patients. PhD by Publication, Queensland University of Technology. | Emmanuel Olorunleke Adewuyi Thesis (PDF 14MB) Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. | Description This PhD project advances our understanding of the relationship between endometriosis and its common comorbid disorders with a focus on asthma, depression, and migraine. Appropriate sets of well-regarded statistical genetic approaches were utilised in the analysis of world-leading genetic data. Findings confirm a comorbid association between endometriosis and each of asthma, depression, and migraine, largely due to shared genetics and biological mechanisms. Causality assessment suggests a potential causal relationship between endometriosis and depression. Further analyses implicate causal links between each of endometriosis and depression and at least one abnormal condition of gastric mucosa—gastritis and gastroesophageal reflux disease. Impact and interest: Citation counts are sourced monthly from Scopus and Web of Science® citation databases. These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards. Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search. Full-text downloads: Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one. | ID Code: | 212039 | |---|---| | Item Type: | QUT Thesis (PhD by Publication) | | Supervisor: | Nyholt, Dale & Griffiths, Lyn | | Keywords: | Endometriosis, Comorbidity, Genetics, Asthma, Depression, Migraine, Causality, GWAS, Genetic overlap, Cross-disoder analysis | | DOI: | 10.5204/thesis.eprints.212039 | | Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences | | Institution: | Queensland University of Technology | | Deposited On: | 25 Aug 2021 10:35 | | Last Modified: | 24 Jan 2025 00:44 | Export: EndNote | Dublin Core | BibTeX Repository Staff Only: item control page

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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