Role of thyroid dysimmunity and thyroid hormones in endometriosis

Marine Peyneau, Niloufar Kavian, Sandrine Chouzenoux, Carole Nicco, Mohamed Jeljeli, Laurie Toullec, Jeanne Reboul‐Marty, Jeanne Reboul-Marty, Camille Chenevier‐Gobeaux, Camille Chenevier-Gobeaux, Fernando M Reis, Pietro Santulli, Piétro Santulli, Ludivine Doridot, Charles Chapron, Frédéric Batteux
Proceedings of the National Academy of Sciences of the United States of America · 2019 · vol. 116(24) , pp. 11894–11899 · doi:10.1073/pnas.1820469116 · PMID:31142643 · PMC6575600 · W2947437690
article OA: bronze CC0 ⤵ 26 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that thyroid hormones, particularly TSH, promote eutopic and ectopic endometrial cell proliferation and oxidative stress in endometriosis, and thyroid disorders are linked to worse symptoms and disease severity.

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Abstract

Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Thyroid Gland Thyroid Hormones Animals Cell Proliferation Cell Proliferation Endometriosis Endometrium Endometrium Female Humans Mice Mice, Inbred BALB C Mice, Inbred C57BL Reactive Oxygen Species Reactive Oxygen Species Retrospective Studies Thyroid Gland Thyroid Hormones Thyrotropin

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References (45)

Cited by (26)

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