Endometrial Polyps in Women Affected by Levothyroxine-Treated Hypothyroidism—Histological Features, Immunohistochemical Findings, and Possible Explanation of Etiopathogenic Mechanism: A Pilot Study

Carlo Saccardi, Salvatore Gizzo, Kathrin Ludwig, Maria Guido, Mara Scarton, Michele Gangemi, Raffaele Tinelli, Pietro Litta
In: BioMed Research International · 2013 · vol. 2013 , pp. 1–5 · doi:10.1155/2013/503419 · PMID:24058909 · W2059910402
article OA: hybrid CC0 ⤵ 6 in-corpus citations
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This pilot study compared endometrial polyps in hypothyroid women treated with levothyroxine to controls, finding higher estrogen receptor expression in stromal cells in the treated group, suggesting a possible dual mechanism involving TSH and exogenous thyroxine.

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Abstract

The aim of the study was to investigate the possible overexpression of estrogen (ERs) and progesterone (PRs) receptors both in EPs glandular and stromal cells in postmenopausal women with levothyroxine-treated hypothyroidism in comparison to EPs detected in women with physiological thyroid hormone levels. During the study period (January-February 2013) 22 patients were eligible (12 treated, 10 controls). The two groups were homogenous for general, EPs sonographic and hysteroscopic features. None of the cases of atypia was found. Immunohistochemistry showed that the two groups were similar for ERs and PRs intensity rates in EPs glandular cells despite a trend of ERs percentage expression more than 60% in 2/3 of treated patients versus 1/3 of controls. In stromal EPs components, ERs intensity was high positive in 10 (83,3%) treated cases while it was high positive in 1 control (10%). Percentage of ERs stromal expression showed a different trend between the two groups despite a borderline statistical significance. Our hypothesis is based on a possible double action of hypothyroidism and thyroxine intake: the subclinical TSH increased levels and its possible circadian oscillation could stimulate the endometrial TSHRs (increasing type 2 DIO activity); the circulating levels of exogenous thyroxine could be locally metabolized in active form by type 2 DIO stimulating ERs.

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