Endometriosis and Infertility: The Comorbidities

The prevalence of infertility in women with endometriosis is very high and the disease is one of the main causes of female infertility. The coexistence with gynecological (uterine fibroids, adenomyosis, and polycystic ovary syndrome) and systemic comorbidities (autoimmune diseases, inflammatory diseases, mental health disorders, and migraine) contributes in different ways to the associated infertility. The diagnosis of concomitant gynecological and systemic conditions affecting fertility is critical to define a more comprehensive counseling and a better plan for reproduction. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

de Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376(9742):730–8. Tomassetti C, D’Hooghe T. Endometriosis and infertility: insights into the causal link and management strategies. Best Pract Res Clin Obstet Gynaecol. 2018;51:25–33. Capezzuoli T, Vannuccini S, Fantappiè G, Orlandi G, Rizzello F, Coccia ME, Petraglia F. Ultrasound findings in infertile women with endometriosis: evidence of concomitant uterine disorders. Gynecol Endocrinol. 2020;36(9):808–12. Chen H, Vannuccini S, Capezzuoli T, Ceccaroni M, Mubiao L, Shuting H, Wu Y, Huang H, Petraglia F. Comorbidities and quality of life in women undergoing first surgery for endometriosis: differences between Chinese and Italian population. Reprod Sci. 2021; https://doi.org/10.1007/s43032-021-00487-5. Epub ahead of print Vannuccini S, Petraglia F. Recent advances in understanding and managing adenomyosis. F1000Res. 2019;8:283. Dior UP, Nisbet D, Fung JN, et al. The association of sonographic evidence of adenomyosis with severe endometriosis and gene expression in eutopic endometrium. J Minim Invasive Gynecol. 2019;26(5):941–8. Naftalin J, Hoo W, Pateman K, et al. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012;27(12):3432–9. Di Donato N, Montanari G, Benfenati A, et al. Prevalence of adenomyosis in women undergoing surgery for endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014;181:289–93. Eisenberg VH, Arbib N, Schiff E, et al. Sonographic signs of adenomyosis are prevalent in women undergoing surgery for endometriosis and may suggest a higher risk of infertility. Biomed Res Int. 2017;2017:1–9. Lazzeri L, Di Giovanni A, Exacoustos C, et al. Preoperative and postoperative clinical and transvaginal ultrasound findings of adenomyosis in patients with deep infiltrating endometriosis. Reprod Sci. 2014;21(8):1027–33. Chapron C, Tosti C, Marcellin L, et al. Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Hum Reprod. 2017;32(7):1393–401. Vannuccini S, Tosti C, Carmona F, et al. Pathogenesis of adenomyosis: an update on molecular mechanisms. Reprod Biomed Online. 2017;35(5):592–601. Barrier BF, Malinowski MJ, Dick EJ, et al. Adenomyosis in the baboon is associated with primary infertility. Fertil Steril. 2004;82:1091–4. Vercellini P, Bonfanti I, Berlanda N. Adenomyosis and infertility: is there a causal link? Expert Rev Endocrinol Metab. 2019;14(6):365–7. Zepiridis LI, Grimbizis GF, Tarlatzis BC. Infertility and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:66–73. Vlahos NF, Theodoridis TD, Partsinevelos GA. Myomas and adenomyosis: impact on reproductive outcome. Biomed Res Int. 2017;2017:1–14. Uimari O, Jarvela I, Ryyn€anen M. Do symptomatic endometriosis and uterine fibroids appear together? J Hum Reprod Sci. 2011;4(1):34–8. Naphatthalung W, Cheewadhanaraks S. Prevalence of endometriosis among patients with adenomyosis and/or myoma uteri scheduled for a hysterectomy. J Med Assoc Thail. 2012;95(9):1136–40. Tanmahasamut P, Noothong S, Sanga-Areekul N, et al. Prevalence of endometriosis in women undergoing surgery for benign gynecologic diseases. J Med Assoc Thail. 2014;97(2):147–52. Maclaran K, Agarwal N, Odejinmi F. Co-existence of uterine myomas and endometriosis in women undergoing laparoscopic myomectomy: risk factors and surgical implications. J Minim Invasive Gynecol. 2014;21(6):1086–90. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14:270–84. Hager M, Wenzl R, Riesenhuber S, Marschalek J, Kuessel L, Mayrhofer D, Ristl R, Kurz C, Ott J. The prevalence of incidental endometriosis in women undergoing laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome: a retrospective cohort study and meta-analysis. J Clin Med. 2019;8(8):1210. Oliveira RDE, Adami F, Mafra FA, Bianco B, Vilarino FL, Barbosa CP. Causes of endometriosis and prevalent infertility in patients undergoing laparoscopy without achieving pregnancy. Minerva Gynecol. 2016;68(3):250–8. Kvaskoff M, Mu F, Terry KL, Harris HR, Poole EM, Farland L, et al. Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. 2015;21:500–16. Surrey ES, Soliman AM, Johnson SJ, Davis M, Castelli-Haley J, Snabes MC. Risk of developing comorbidities among women with endometriosis: a retrospective matched cohort study. J Women's Health. 2018;27:1114–23. Vannuccini S, Lazzeri L, Orlandini C, Morgante G, Bifulco G, Fagiolini A, et al. Mental health, pain symptoms and systemic comorbidities in women with endometriosis: a cross-sectional study. J Psychosom Obstet Gynaecol. 2018;39:315–20. Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, Missmer SA, Rahmioglu N, Zondervan KT, Becker CM. The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(4):486–503. Khizroeva J, Nalli C, Bitsadze V, Lojacono A, Zatti S, Andreoli L, Tincani A, Shoenfeld Y, Makatsariya A. Infertility in women with systemic autoimmune diseases. Best Pract Res Clin Endocrinol Metab. 2019;33(6):101369. Porpora MG, Scaramuzzino S, Sangiuliano C, Piacenti I, Bonanni V, Piccioni MG, Ostuni R, Masciullo L, Benedetti Panici PL. High prevalence of autoimmune diseases in women with endometriosis: a case-control study. Gynecol Endocrinol. 2020;36(4):356–9. Harris HR, Costenbader KH, Mu F, Kvaskoff M, Malspeis S, Karlson EW, Missmer SA. Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses' Health Study II. Ann Rheum Dis. 2016;75(7):1279–84. Tiniakou E, Costenbader KH, Kriegel MA. Sex-specific environmental influences on the development of autoimmune diseases. Clin Immunol. 2013;149:182–91. Peyneau M, Kavian N, Chouzenoux S, Nicco C, Jeljeli M, Toullec L, Reboul-Marty J, Chenevier-Gobeaux C, Reis FM, Santulli P, Doridot L, Chapron C, Batteux F. Role of thyroid dysimmunity and thyroid hormones in endometriosis. Proc Natl Acad Sci U S A. 2019;116(24):11894–9. Jess T, Frisch M, Jørgensen KT, Pedersen BV, Nielsen NM. Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study. Gut. 2012;61:1279–83. Chiaffarino F, Cipriani S, Ricci E, Roncella E, Mauri PA, Parazzini F, Vercellini P. Endometriosis and inflammatory bowel disease: a systematic review of the literature. Eur J Obstet Gynecol Reprod Biol. 2020;252:246–51. Martin J, Kane SV, Feagins LA. Fertility and contraception in women with inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2016;12(2):101–9. Truta B. The impact of inflammatory bowel disease on women's lives. Curr Opin Gastroenterol. 2021; https://doi.org/10.1097/MOG.0000000000000736. Epub ahead of print Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur J Obstet Gynecol Reprod Biol. 2017;209:3–7. Cirillo M, Coccia ME, Petraglia F, Fatini C. Role of endometriosis in defining cardiovascular risk: a gender medicine approach for women's health. Hum Fertil (Camb). 2021;30:1–9. Mu F, Rich-Edwards J, Rimm EB, Spiegelman D, Forman JP, Missmer SA. Association between endometriosis and hypercholesterolemia or hypertension. Hypertension. 2017;70(1):59–65. Coratti F, Vannuccini S, Foppa C, Staderini F, Coratti A, Cianchi F, Petraglia F. Emergency surgery for appendectomy and incidental diagnosis of superficial peritoneal endometriosis in fertile age women. Reprod Biomed Online. 2020;41(4):729–33. Clarizia R, Capezzuoli T, Ceccarello M, Zorzi C, Stepniewska A, Roviglione G, Mautone D, Petraglia F, Ceccaroni M. Inflammation calls for more: severe pelvic inflammatory disease with or without endometriosis. Outcomes on 311 laparoscopically treated women. J Gynecol Obstet Hum Reprod. 2021;50(3):101811. Wu CC, Chung SD, Lin HC. Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: a population-based study. Neurourol Urodyn. 2018;37(4):1413–8. Carbone MG, Campo G, Papaleo E, Marazziti D, Maremmani I. The importance of a multi-disciplinary approach to the endometriotic patients: the relationship between endometriosis and psychic vulnerability. J Clin Med. 2021;10(8):1616. Miller JA, Missmer SA, Vitonis AF, Sarda V, Laufer MR, DiVasta AD. Prevalence of migraines in adolescents with endometriosis. Fertil Steril. 2018;109(4):685–90. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Capezzuoli, T., Sorbi, F., Vannuccini, S., Clarizia, R., Ceccaroni, M., Petraglia, F. (2024). Endometriosis and Infertility: The Comorbidities. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_2 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_2 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)