Evaluation of the relationship between thyroid hormones and endometriosis: a clinical investigation

Morteza Sanei Taheri, Majid Valiyan Boroujeni, Zahra Mahboubi Fouladi, Shahla Noori Ardebili, Samaneh Chegeni, Yashar Moharamzad, Simin Abniki, Sara Hasanzadeh, Siamak Hasanzadeh
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2025 · vol. 14(9) , pp. 2846–2852 · doi:10.18203/2320-1770.ijrcog20252708 · W4413813426
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This clinical investigation found elevated anti-TPO levels associated with stage 2 endometriosis and higher pain in moderate disease, while TSH, T3, and Free T4 showed no significant correlations.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional clinical investigation assessed whether thyroid hormone levels and thyroid autoimmunity markers correlate with endometriosis severity. Participants with endometriosis at two hospitals underwent clinical evaluation, ultrasound staging/markers, and measurements of thyroid hormones (TSH, T3, free T4) and anti-TPO, with statistical analyses examining associations with disease stage and pain severity. Anti-TPO levels were significantly associated with UBESS stage 2, and pain severity was higher in moderate disease, while TSH, T3, and free T4 showed no significant correlations with stage or pain; adhesion-related features were associated with nodule presence and uterosacral ligament thickness. This paper is centrally about endometriosis — it evaluates correlations between thyroid hormones/anti-TPO and endometriosis severity and ultrasound markers.

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Abstract

Background: Endometriosis is a chronic gynecological condition that affects reproductive-aged women. This study evaluated the correlation between thyroid hormone levels and endometriosis severity. Methods: A cross-sectional study was conducted at Shohada Tajrish Hospital and Atieh Hospital from September 2024 to April 2025. Participants diagnosed with endometriosis underwent clinical, ultrasound, and thyroid hormone assessments. Statistical analyses were used to explore correlations between hormone levels and endometriosis severity. Results: Significant associations were found between anti-TPO levels and UBESS stage 2. Pain severity was higher in moderate disease. However, TSH, T3, and Free T4 levels showed no significant correlations with disease stage or pain severity. Adhesion levels were associated with nodule presence and uterosacral ligament thickness. Conclusions: Elevated anti-TPO levels may indicate autoimmune involvement in moderate endometriosis. Structural markers on ultrasound, such as nodule count and USL thickness, may predict disease severity.

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Outcome instruments

VAS-pain NRS-pain

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

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last seen: 2026-06-10T17:14:06.276822+00:00
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