The Impact of Endometriosis on the Quality of Life and the Incidence of Depression—A Cohort Study

Damian Warzecha, Iwona Szymusik, Miroslaw Wielgos, Mirosław Wielgoś, Bronislawa Pietrzak, Bronisława Pietrzak
International journal of environmental research and public health · 2020 · vol. 17(10) , pp. 3641 · doi:10.3390/ijerph17103641 · PMID:32455821 · PMC7277332 · W3026894521
article OA: gold CC0 ⤵ 105 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that chronic pelvic pain and painful defecation increased depression risk in endometriosis patients, while disease stage correlated with infertility, and pain intensity was independent of disease stage.

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Abstract

The objective was to evaluate the quality of life and the incidence of depression among women suffering from endometriosis. Afterwards, the dependency between pelvic pain, its severity and stages of endometriosis were analyzed. The study protocol included women of reproductive ages with confirmed endometriosis. The stage of disease was conferred according to the ASRM (American Society of Reproductive Medicine) classification. Women fulfilled two questionnaires: “WERF EPHect Clinical Questionnaire” and self-prepared survey about fertility disorders. The study group comprised of 246 respondents. A total of 77.2% of women were symptomatic. The most common complaints were chronic pelvic pain (CPP, 71.1%), dysmenorrhea (69.0%) and dyspareunia (45.2%). Intensity of pain was independent from the stage of endometriosis. The incidence of infertility and the time to conceive increased with the stage of disease (stage 1—52.8%, 3.4 years; stage 2—66.7%, 4.1 years; stage 3—61.3%, 3.7 years; stage 4—96%, 6.1years; p = 0.02 and 0.03, respectively). The prevalence of depression was positively correlated with the beginning of dyspareunia (14.5 vs. 19.6 years old., p = 0.002). CPP (OR(odds ratio) = 3.8, 95% CI 1.2–12.8, p = 0.04) and painful defecation (OR = 7.7, 95% CI 1.4–42.3, p = 0.01) increased the risk of depression. Symptoms related to endometriosis and severity of pain correlate with the prevalence of depression. Stage of endometriosis is significantly related to the prevalence of infertility.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_paindyspareuniainfertility

MeSH descriptors

Depression Endometriosis Endometriosis Endometriosis Quality of Life Adult Cohort Studies Dysmenorrhea Female Humans Incidence

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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