The Impact of Endometriosis Diagnosis on Women's Mental Health-A Cross-Sectional Study

Sajid Hameed, M. Shafique Shafique, Zartashia Anjum, Huma Tahseen, Amna Mannan, Azharul Mannan, Nazia Ayyub Butt, Nadeem Shafique Butt, Nimra Shafique, N. Shafique, Aqsa Tariq
In: Pakistan Journal of Health Sciences · 2024 · pp. 112–117 · doi:10.54393/pjhs.v5i09.1613 · W4403472016
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional study found that a positive endometriosis diagnosis in sub-fertile women significantly correlated with higher anxiety and depression scores, particularly in those with worse endometriosis-related health profiles.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This cross-sectional study evaluated how receiving an endometriosis diagnosis relates to women’s mental health, using baseline data, the Endometriosis Health Profile (EHP-30), and Hospital Anxiety and Depression Scale scores in 200 sub-fertile women recruited through non-probability sampling. Among participants, 28 (14%) had endometriosis, and endometriosis-related health status measures were significantly correlated with anxiety and depression (with reported p-values of 0.007 and 0.000). The highest prevalence of severe anxiety and depression occurred in women with the “bad” possible endometriosis-related health profiles, and the study reports that endometriosis positivity correlated with age. The paper’s main limitation is its cross-sectional design and non-probability sampling, which restricts causal inference and generalizability. This paper is centrally about endometriosis — it specifically analyzes how endometriosis diagnosis and EHP-30 health profiles relate to anxiety, depression, and quality of life in sub-fertile women.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a chronic condition where tissue similar to endometrium grows outside the uterus. It affects the social and psychological life of women. Objective: To evaluate the impact of endometriosis diagnosis on women's mental health. Methods: In this cross-sectional study basal data, Endometriosis Health Profile (EHP-30) statuses, and Hospital Anxiety and Depression scale scores were collected from 200 sub-fertile women who were sampled using a non-probability sampling technique. Frequency distribution and chi-square (X2) analysis were performed using IBM SPSS® version 26.0. Results: Out of 200 sub-fertile women 28 (14%) had endometriosis. Positive endometriosis significantly correlated with age (0.09<0.1). The endometriosis-related health statuses significantly correlated with anxiety and depression with two-sided asymptomatic significances of 0.007 (<0.05) and 0.000 (< 0.05) respectively. The highest prevalence of severe anxiety and depression was present in women with bad possible health profiles related to endometriosis. Conclusions: It was concluded that endometriosis aggravates with age and its positive diagnosis has a strong negative impact on the social and psychological health of the patients.
Full text 7,848 characters · extracted from oa-doi-fallback · click to expand
The Impact of Endometriosis Diagnosis on Women's Mental Health-A Cross-Sectional Study Endometriosis Diagnosis on Women's Mental Health DOI: https://doi.org/10.54393/pjhs.v5i09.1613Keywords: Endometriosis, Women's Mental Health, Quality of Life, Endometriosis Health Profile-30, Hospital Anxiety, Depression ScaleAbstract Endometriosis is a chronic condition where tissue similar to endometrium grows outside the uterus. It affects the social and psychological life of women. Objective: To evaluate the impact of endometriosis diagnosis on women's mental health. Methods: In this cross-sectional study basal data, Endometriosis Health Profile (EHP-30) statuses, and Hospital Anxiety and Depression scale scores were collected from 200 sub-fertile women who were sampled using a non-probability sampling technique. Frequency distribution and chi-square (X2) analysis were performed using IBM SPSS® version 26.0. Results: Out of 200 sub-fertile women 28 (14%) had endometriosis. Positive endometriosis significantly correlated with age (0.09<0.1). The endometriosis-related health statuses significantly correlated with anxiety and depression with two-sided asymptomatic significances of 0.007 (<0.05) and 0.000 (< 0.05) respectively. The highest prevalence of severe anxiety and depression was present in women with bad possible health profiles related to endometriosis. Conclusions: It was concluded that endometriosis aggravates with age and its positive diagnosis has a strong negative impact on the social and psychological health of the patients. References Saunders PT and Horne AW. Endometriosis: Etiology, Pathobiology, and Therapeutic Prospects. Cell. 2021 May; 184(11): 2807-24. doi: 10.1016/j.cell.2021.04.041. DOI: https://doi.org/10.1016/j.cell.2021.04.041 Horne AW and Missmer SA. Pathophysiology, Diagnosis, and Management of Endometriosis. British Medical Journal. 2022 Nov: 379. doi: 10.1136/bmj-2022-070750. DOI: https://doi.org/10.1136/bmj-2022-070750 Bulun SE. Endometriosis Caused by Retrograde Menstruation: Now Demonstrated by DNA Evidence. Fertility and Sterility. 2022 Sep; 118(3): 535-6. doi: 10.1016/j.fertnstert.2022.07.012. DOI: https://doi.org/10.1016/j.fertnstert.2022.07.012 Allaire C, Bedaiwy MA, Yong PJ. Diagnosis and Management of Endometriosis. Canadian Medical Association Journal. 2023 Mar; 195(10): E363-71. doi: 10.1503/cmaj.220637. DOI: https://doi.org/10.1503/cmaj.220637 Jones GL, Budds K, Taylor F, Musson D, Raymer J, Churchman D et al. A systematic Review to Determine Use of the Endometriosis Health Profiles to Measure Quality of Life Outcomes in Women with Endometriosis. Human Reproduction Update. 2024 Mar; 30(2): 186-214. doi: 10.1093/humupd/dmad029. DOI: https://doi.org/10.1093/humupd/dmad029 Norinho P, Martins MM, Ferreira H. A Systematic Review on the Effects of Endometriosis on Sexuality and Couple’s Relationship. Facts, Views and Vision in Obstetrics and Gynecology. 2020 Sep; 12(3): 197-205. Tabbsum T, Nafees S, Hayes T, ul Hassan SM, Sattar A. Frequency of Endometriosis in Females with Infertility Undergoing Diagnostic Laparoscopy: Endometriosis in Females with Infertility. Pakistan Journal of Health Sciences. 2022 Aug; 3(3): 13-6. doi: 10.54393/pjhs.v3i03.65. DOI: https://doi.org/10.54393/pjhs.v3i03.65 Rees M, Kiemle G, Slade P. Psychological Variables and Quality of Life in Women with Endometriosis. Journal of Psychosomatic Obstetrics and Gynecology. 2022 Jan; 43(1): 58-65. doi: 10.1080/0167482X.2020.1784874. DOI: https://doi.org/10.1080/0167482X.2020.1784874 Moradi M, Parker M, Sneddon A, Lopez V, Ellwood D. Impact of Endometriosis on Women’s Lives: A Qualitative Study. BioMed Central Women's Health. 2014 Dec; 14(1): 1-2. doi: 10.1186/1472-6874-14-123. DOI: https://doi.org/10.1186/1472-6874-14-123 Warzecha D, Szymusik I, Wielgos M, Pietrzak B. The Impact of Endometriosis on the Quality of Life and the Incidence of Depression—A Cohort Study. International Journal of Environmental Research and Public Health. 2020 May; 17(10): 3641. doi: 10.3390/ijerph17103641. DOI: https://doi.org/10.3390/ijerph17103641 Gambadauro P, Carli V, Hadlaczky G. Depressive Symptoms among Women with Endometriosis: A Systematic Review and Meta-Analysis. American Journal of Obstetrics and Gynecology. 2019 Mar; 220(3): 230-41. doi: 10.1016/j.ajog.2018.11.123. DOI: https://doi.org/10.1016/j.ajog.2018.11.123 Bell RJ, Robinson PJ, Skiba MA, Islam RM, Hemachandra C, Davis SR. The Impact of Endometriosis on Work Ability in Young Australian Women. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2023 Aug; 63(4): 556-63. doi: 10.1111/ajo.13683. DOI: https://doi.org/10.1111/ajo.13683 Navarro PA. Infertility Associated to Endometriosis: Clarifying Some Important Controversies. Revista Brasileira de Ginecologia e Obstetrícia. 2019 Sep; 41(9): 523-4. doi: 10.1055/s-0039-1697638. DOI: https://doi.org/10.1055/s-0039-1697638 Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM. Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews. 2020(10). DOI: https://doi.org/10.1002/14651858.CD011031.pub3 Grundström H, Rauden A, Wikman P, Olovsson M. Psychometric Evaluation of the Swedish Version of the 30-Item Endometriosis Health Profile (EHP-30). BioMed Central Women's Health. 2020 Dec; 20: 1-8. doi: 10.1186/s12905-020-01067-6. DOI: https://doi.org/10.1186/s12905-020-01067-6 Garaiman A, Mihai C, Dobrota R, Jordan S, Maurer B, Flemming J et al. The Hospital Anxiety and Depression Scale in Patients with Systemic Sclerosis: A Psychometric and Factor Analysis in A Monocentric Cohort. Clinical and Experimental Rheumatology. 2021 Apr; 39(Suppl 131): 34-42. doi: 10.55563/clinexprheumatol/qo1ehz. DOI: https://doi.org/10.55563/clinexprheumatol/qo1ehz Gardezi SFZ, Mahmood S, Ahmad A. Role of Endometriosis as A Risk Factor for the Females with Primary Sub-Fertility. Journal of Medicine Physiology and Biophysics. 2019 May; 55: 49-53. doi: 10.7176/JMPB/55-13. DOI: https://doi.org/10.7176/JMPB/55-13 Metzler JM, Imesch P, Dietrich H, Knobel C, Portmann L, Neumeier MS et al. Impact of Family History for Endometriosis, Migraine, Depression and Early Menopause on Endometriosis Symptoms, Localization and Stage: A Case Control Study. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2024 Feb; 293: 36-43. doi: 10.1016/j.ejogrb.2023.12.016. DOI: https://doi.org/10.1016/j.ejogrb.2023.12.016 Ahmed DP, Chowdhury D, Mahmud D. Demographic and Clinical Features of Patients with Subfertility. Scholars International Journal of Obstetrics and Gynecology. 2021 Mar; 4(3): 76-81. doi: 10.36348/sijog.2021.v04i03.007. DOI: https://doi.org/10.36348/sijog.2021.v04i03.007 Silva FP, Yela DA, de Barros Meneguetti M, Torelli F, Gibran L, Benetti-Pinto CL. Assessment of Quality of Life, Psychological Aspects, and Sexual Function of Women with Endometriosis According to Pain and Infertility: A Cross-Sectional Study. Archives of Gynecology and Obstetrics. 2024 Jun; 309(6): 2741-9. doi: 10.1007/s00404-024-07464-8. DOI: https://doi.org/10.1007/s00404-024-07464-8 Szypłowska M, Tarkowski R, Kułak K. The impact of Endometriosis on Depressive and Anxiety Symptoms and Quality of Life: A Systematic Review. Frontiers in Public Health. 2023 Sep; 11: 1230303. doi: 10.3389/fpubh.2023.1230303. DOI: https://doi.org/10.3389/fpubh.2023.1230303 Downloads Published How to Cite Issue Section License Copyright (c) 2024 Pakistan Journal of Health Sciences (Lahore) This work is licensed under a Creative Commons Attribution 4.0 International License. This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Outcome instruments

EHP-30

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK