Infertility Associated to Endometriosis: Clarifying Some Important Controversies

Paula Andrea Navarro
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019 · vol. 41(09) , pp. 523–524 · doi:10.1055/s-0039-1697638 · PMID:31546274 · W2976858597
editorial OA: diamond CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis, a common gynecological disease affecting 10% of reproductive-aged women, is strongly linked to infertility, with over 30% of infertile women having the condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This 2019 editorial reviews controversies around infertility in endometriosis, focusing on evidence about whether minimal/mild disease affects natural conception and whether IVF/ICSI outcomes are worse in endometriosis patients, especially by disease stage. It summarizes older studies suggesting similar fecundity in minimal/mild endometriosis versus unexplained infertility, but also cites trials and retrospective data indicating lower cumulative pregnancy rates even in early stages, while noting that the major IVF meta-analysis from 2002 largely drew on studies conducted before modern ovarian stimulation techniques. For IVF/ICSI, it reports newer meta-analytic data showing similar live birth rates overall but lower clinical pregnancy rates and fewer retrieved oocytes in endometriosis, with worse live birth outcomes mainly in stages III–IV, and it adds group data that endometriosis is associated with poorer ovarian reserve yet similar live birth chances when ovarian reserve is comparable. This paper is centrally about endometriosis — it clarifies controversies linking endometriosis stage to natural conception and IVF/ICSI outcomes.

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Abstract

Endometriosis is an estrogen-dependent gynecological disease characterized by the presence and growth of endometrial tissue (glands and/or stroma) outside the uterine cavity.[1] The disease affects ∼ 10% of women of reproductive age[2] and is strongly associated with infertility.[3] It is estimated that more than 30% of infertile women have endometriosis[2] and that 30 to 50% of these women report difficulties in getting pregnant.[4]

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Adult Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Cited by (5)

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