Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress

A Augoulea, Areti Augoulea, A Alexandrou, Andreas Alexandrou, Maria Creatsa, M Creatsa, Nikolaos Vrachnis, N Vrachnis, Ιrene Lambrinoudaki, I Lambrinoudaki
Archives of gynecology and obstetrics · 2012 · vol. 286(1) , pp. 99–103 · doi:10.1007/s00404-012-2357-8 · PMID:22546953 · W2058161683
review OA: closed CC0 ⤵ 100 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This literature review examines genetic abnormalities, inflammation, and oxidative stress as contributing factors to the pathogenesis of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper is a literature review on the unresolved multifactorial etiology of endometriosis, focusing on how genetic abnormalities, inflammatory activity, and oxidative stress may contribute to disease pathogenesis. It synthesizes evidence from studies examining susceptibility-related genetic variants (including those in detoxification and hormone-related pathways) and from research characterizing chronic inflammatory and oxidative alterations. A key finding is that the reviewed body of work links predisposition to endometriosis with interactions among genetics, inflammation, and oxidative stress, including iron- and NF-κB–related considerations. The main limitation is that, as a review, it does not present new experimental data and the multifactorial mechanisms remain incompletely resolved. This paper is centrally about endometriosis — it reviews genetic, inflammatory, and oxidative-stress roles in endometriosis pathogenesis, with some genetic references also mentioning adenomyosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Inflammation Oxidative Stress Endometriosis Female Humans Inflammation

Citation neighborhood

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References (81)

Cited by (50)

Source provenance

europepmc
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License: CC0 · commercial use OK