Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells

Wang XR, Xue-Rong Wang, Xuerong Wang, Hao HG, Hong-guang Hao, Lan H. Chu, Lan Chu, Chu L
Microbial pathogenesis · 2017 · vol. 109 , pp. 110–113 · doi:10.1016/j.micpath.2017.05.032 · PMID:28552807 · W2617869492
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Glycyrrhizin was found to inhibit the production of inflammatory mediators in endometrial epithelial cells stimulated by lipopolysaccharide.

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Abstract

Endometriosis is a continuous inflammation of uterine endometrium that usually affects women of reproductive age. Glycyrrhizin, a triterpene isolated from the roots and rhizomes of licorice (Glycyrrhiza glabra), has been known to have anti-inflammatory effect. The purpose of this study was to investigate the anti-inflammatory effect of glycyrrhizin on LPS-stimulated mouse endometrial epithelial cells (MEEC). The levels of TNF-α, IL-1β, and PGE2 were measured by ELISA. The expression of COX-2, iNOS, TLR4, and NF-ĸB were detected by western blot analysis. The results showed that glycyrrhizin significantly suppressed LPS-induced TNF-α, IL-1β, NO, and PGE2 production. Also, LPS-induced iNOS and COX-2 expression were attenuated by glycyrrhizin. Furthermore, glycyrrhizin significantly attenuated TLR4 expression and NF-κB activation induced by LPS in MEEC. In conclusion, the present study demonstrated that glycyrrhizin inhibited LPS-induced inflammatory response by inhibiting TLR4 signaling pathway in MEEC. Glycyrrhizin may be used as a potential agent for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Epithelial Cells Glycyrrhizic Acid Inflammation Mediators Animals Anti-Inflammatory Agents Cell Culture Techniques Cell Line Cell Survival Cell Survival Cyclooxygenase 2 Cyclooxygenase 2 Cytokines Cytokines Dinoprostone Dinoprostone Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Epithelial Cells

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