From Endometriosis to Cancer: Spotlight on Intracellular Signaling Cascades and MicroRNAs

Increasingly sophisticated information has started to shed light on essential role of signal transduction cascades in endometriosis and how these pathways promote transformations from benign to premalignant endometriosis. It is becoming progressively more understandable that genetic/epigenetic mutations, inactivation of tumor suppressors, aberrant expression of different microRNAs play decisive role in malignant transformation of endometriosis. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol. 2004;160:784–96. Rafique S, Decherney AH. Medical management of endometriosis. Clin Obstet Gynecol. 2017;60:485. https://doi.org/10.1097/GRF.0000000000000292. [Epub ahead of print] Porpora MG, Koninckx PR, Piazze J, Natili M, Colagrande S, Cosmi EV. Correlation between endometriosis and pelvic pain. J Am Assoc Gynecol Laparosc. 1999;6(4):429–34. Szendei G, Hernádi Z, Dévényi N, Csapó Z. Is there any correlation between stages of endometriosis and severity of chronic pelvic pain? Possibilities of treatment. Gynecol Endocrinol. 2005;21(2):93–100. Cavaggioni G, Lia C, Resta S, Antonielli T, Benedetti Panici P, Megiorni F, Porpora MG. Are mood and anxiety disorders and alexithymia associated with endometriosis? A preliminary study. Biomed Res Int. 2014;22:786830. Low WY, Edelmann RJ. Psychosocial aspects of endometriosis: a review. J Psychosom Obstet Gynaecol. 1991;12(1):3–12. Gupta S, Agarwal A, Sekhon L, Krajcir N, Cocuzza M, Falcone T. Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. Minerva Ginecol. 2006;58(6):527–51. Anastasi E, Manganaro L, Granato T, Benedetti Panici P, Frati L, Porpora MG. Is CA72-4 a useful biomarker in differential diagnosis between ovarian endometrioma and epithelial ovarian cancer? Dis Markers. 2013;35(5):331–5. Bast RC Jr, Klug TL. St. John E. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983;309(15):883–7. Mckinnon B, Mueller MD, Nirgianakis K, Bersinger NA. Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125. Mol Med Rep. 2015;12(4):5179–84. Kadija S, Stefanovic A, Jeremik K, Radojevic MM, Nikolic L, Markovic I, Atanackovic J. The utility of human epididymal protein 4, cancer antigen 125, and risk for malignancy algorithm in ovarian cancer and endometriosis. Int J Gynecol Cancer. 2012;22(2):238–44. Chung SY, Kim SJ, Kim TH, Ryu WG, Park SJ, Lee DY, Paik HC, Kim HJ, Cho SH, Kim JK, Park KJ, Ryu YH. Computed tomography findings of pathologically confirmed pulmonary parenchymal endometriosis. J Comput Assist Tomogr. 2005;29:815–8. Fraser IS. Recognising, understanding and managing endometriosis. J Reprod Sci. 2008;1:56–64. Halme J, Hammond M, Hulka J, Raj SG, Talbert LM. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64:151–4. Sampson J. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69. Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A. Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997;176:572–9. Swiersz L. Role of endometriosis in cancer and tumour development. Ann N Y Acad Sci. 2002;955:281–92. Heidemann LN, Hartwell D, Heidemann CH, Jochumsen KM. The relation between endometriosis and ovarian cancer – a review. Acta Obstet Gynecol Scand. 2014;93:20–31. Kobayashi H, Sumimoto K, Moniwa N, Imai M, Takakura K, Kuromaki T, Morioka E, Arisawa K, Terao T. Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan. Int J Gynecol Cancer. 2007;17:37–43. Rossing MA, Cushing-Haugen KL, Wicklund KG, Doherty JA, Weiss NS. Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery. Cancer Causes Control. 2008;19:1357–64. Vigano P, Somigliana E, Parazzini F, Vercellini P. Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer. Fertil Steril. 2007;88:588–93. Guo SW. The association of endometriosis with ovarian cancer: a critical review of epidemiological data, Endometriosis, vol. 22. Berlin: Springer; 2014. p. 363–84. Bonous V, Ferrero A, Fuso L, Ravarino N, Ceccaroni M, Menato G, Biglia N. Endometriosis-associated ovarian cancer: a distinct clinical entity? Anticancer Res. 2016;36(7):3445–9. Yun BH, Chon SJ, Choi YS, Cho S, Lee BS, Seo SK. Pathophysiology of endometriosis: role of high mobility group box-1 and toll-like receptor 4 developing inflammation in endometrium. PLoS One. 2016;11(2):e0148165. https://doi.org/10.1371/journal.pone.0148165 Worley MJ Jr, Liu S, Hua Y, Kwok JS, Samuel A, Hou L, Shoni M, Lu S, Sandberg EM, Keryan A, Wu D, Ng SK, Kuo WP, Parra-Herran CE, Tsui SK, Welch W, Crum C, Berkowitz RS, Ng SW. Molecular changes in endometriosis-associated ovarian clear cell carcinoma. Eur J Cancer. 2015;51(13):1831–42. https://doi.org/10.1016/j.ejca.2015.05.011 González-Foruria I, Santulli P, Chouzenoux S, Carmona F, Batteux F, Chapron C. Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity. PLoS One. 2015;10(3):e0119961. https://doi.org/10.1371/journal.pone.0119961 Hsiao KY, Chang N, Tsai JL, Lin SC, Tsai SJ, Wu MH. Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis. Am J Reprod Immunol. 2017;78. https://doi.org/10.1111/aji.12690. Richards EG, Zheng Y, Shenoy CC, Ainsworth AJ, Delaney AA, Jones TL, Khan Z, Daftary GS. KLF11 is an epigenetic mediator of DRD2/dopaminergic signaling in endometriosis. Reprod Sci. 2017;24(8):1129–38. https://doi.org/10.1177/1933719117698582 Marcellin L, Santulli P, Chouzenoux S, Cerles O, Nicco C, Dousset B, Pallardy M, Kerdine-Römer S, Just PA, Chapron C, Batteux F. Alteration of Nrf2 and glutamate cysteine ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis. Free Radic Biol Med. 2017;110:1–10. https://doi.org/10.1016/j.freeradbiomed.2017.04.362 Au HK, Chang JH, Wu YC, Kuo YC, Chen YH, Lee WC, Chang TS, Lan PC, Kuo HC, Lee KL, Lee MT, Tzeng CR, Huang YH. TGF-βI regulates cell migration through pluripotent transcription factor OCT4 in endometriosis. PLoS One. 2015;10(12):e0145256. https://doi.org/10.1371/journal.pone.0145256 Wang XR, Hao HG, Chu L. Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells. Microb Pathog. 2017;109:110–3. https://doi.org/10.1016/j.micpath.2017.05.032 LaGrenade A, Silverberg SG. Ovarian tumors associated with atypical endometriosis. Hum Pathol. 1988;19(9):1080–4. Tang FH, Hsieh TH, Hsu CY, Lin HY, Long CY, Cheng KH, Tsai EM. KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice. Int J Cancer. 2017;140(8):1860–9. https://doi.org/10.1002/ijc.30591 Lakshminarasimhan R, Andreu-Vieyra C, Lawrenson K, Duymich CE, Gayther SA, Liang G, Jones PA. Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells. Cancer Lett. 2017;401:11–9. https://doi.org/10.1016/j.canlet.2017.04.040 Carrarelli P, Funghi L, Ciarmela P, Centini G, Reis FM, Dela Cruz C, Mattei A, Vannuccini S, Petraglia F. Deep infiltrating endometriosis and endometrial adenocarcinoma express high levels of myostatin and its receptors messenger RNAs. Reprod Sci. 2017;24:1577. https://doi.org/10.1177/1933719117698579 Chen X, Yan Q, Li S, Zhou L, Yang H, Yang Y, Liu X, Wan X. Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma. Cancer Lett. 2012;314(1):41–53. https://doi.org/10.1016/j.canlet.2011.09.014 Wu D, Huang HJ, He CN, Wang KY. MicroRNA-199a-3p regulates endometrial cancer cell proliferation by targeting mammalian target of rapamycin (mTOR). Int J Gynecol Cancer. 2013;23(7):1191–7. https://doi.org/10.1097/IGC.0b013e31829ea779 Liu P, Wang C, Ma C, Wu Q, Zhang W, Lao G. MicroRNA-23a regulates epithelial-to-mesenchymal transition in endometrial endometrioid adenocarcinoma by targeting SMAD3. Cancer Cell Int. 2016;16(1):67. https://doi.org/10.1186/s12935-016-0342-1 Li Q, Zhang C, Chen R, Xiong H, Qiu F, Liu S, Zhang M, Wang F, Wang Y, Zhou X, Xiao G, Wang X, Jiang Q. Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. Cancer Lett. 2016;383(1):28–40. https://doi.org/10.1016/j.canlet.2016.09.019 Yoneyama K, Ishibashi O, Kawase R, Kurose K, Takeshita T. miR-200a, miR-200b and miR-429 are onco-miRs that target the PTEN gene in endometrioid endometrial carcinoma. Anticancer Res. 2015;35(3):1401–10. Chen XP, Chen YG, Lan JY, Shen ZJ. MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG. Cancer Lett. 2014;353(2):201–10. https://doi.org/10.1016/j.canlet.2014.07.026. Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noë M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, RC W, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen JD, Wong F, Hasanovic A, Orr N, Zhang M, Popoli M, McMahon W, Wood LD, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang TL, Vogelstein B, Yong PJ, Huntsman DG, Shih IM. Cancer-associated mutations in endometriosis without cancer. N Engl J Med. 2017;376(19):1835–48. https://doi.org/10.1056/NEJMoa1614814 Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2018 Springer International Publishing AG About this chapter Cite this chapter Halim, T.A., Attar, R., Donfrancesco, C., Farooqi, A.A., Zaman, F. (2018). From Endometriosis to Cancer: Spotlight on Intracellular Signaling Cascades and MicroRNAs. In: Fayyaz, S., Farooqi, A. (eds) Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Springer, Cham. https://doi.org/10.1007/978-3-319-71553-7_1 Download citation DOI: https://doi.org/10.1007/978-3-319-71553-7_1 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-71552-0 Online ISBN: 978-3-319-71553-7 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)