Deep Infiltrating Endometriosis and Endometrial Adenocarcinoma Express High Levels of Myostatin and Its Receptors Messenger RNAs

Patrizia Carrarelli, Lucia Funghi, Pasquapina Ciarmela, Gabriele Centini, Fernando M Reis, Cynthia Dela Cruz, Alberto Mattei, Silvia Vannuccini, Felice Petraglia
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 24(12) , pp. 1577–1582 · doi:10.1177/1933719117698579 · PMID:28345488 · W2597716091
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study found higher messenger RNA expression of myostatin and its receptors in deep infiltrating endometriosis and endometrial carcinoma compared to control endometrium.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study measured myostatin mRNA and mRNA for its receptors ALK4, ALK5, and ActRIIB in endometrial tissue from healthy women across the menstrual cycle, and compared expression in tissues from benign conditions (deep infiltrating endometriosis, ovarian endometrioma, and endometrial polyps) and in malignant endometrial adenocarcinoma, using quantitative real-time PCR on RNA from hysteroscopic, laparoscopic, and hysterectomy samples. Myostatin and its receptor mRNAs were expressed throughout the menstrual cycle in healthy endometrium without differences between proliferative and secretory phases. The highest myostatin mRNA expression occurred in deep infiltrating endometriosis and endometrial carcinoma, and myostatin receptor mRNA was also higher in deep infiltrating endometriosis and adenocarcinomas versus control; receptor-specific increases were reported in ovarian endometrioma and polyps. The study’s caveat is that it assessed mRNA expression levels from tissue homogenates, without functional testing of myostatin signaling in this cohort. This paper is centrally about endometriosis — it reports increased myostatin and receptor mRNA expression in deep infiltrating endometriosis alongside endometrial adenocarcinoma.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Carcinoma, Endometrioid Endometrial Neoplasms Endometriosis Myostatin Protein Serine-Threonine Kinases Activin Receptors, Type I Activin Receptors, Type I Activin Receptors, Type II Activin Receptors, Type II Adult Aged Carcinoma, Endometrioid Endometrial Neoplasms Endometriosis Female Gene Expression Humans Menstrual Cycle Middle Aged Myostatin

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