p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival

Hakan Cakmak, Hakan Çakmak, Yasemin Seval, Yasemin Seval-Celik, Sefa Arlıer, Sefa Arlier, Ozlem Guzeloglu‐Kayisli, Ozlem Guzeloglu-Kayisli, Frederick Schatz, Aydin Arici, Aydın Arıcı, Umit A Kayisli
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(4) , pp. 587–597 · doi:10.1177/1933719117725828 · PMID:28845752 · W2746286638
article OA: closed CC0 ⤵ 22 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Increased p38 MAPK activity in endometriotic cells correlates with IL-8 expression and promotes inflammation but does not affect cell survival.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The study compared p38 MAPK signaling in normal human endometrium versus eutopic and ectopic endometriosis, using immunohistochemistry for total and phosphorylated p38 and correlating its activity with IL-8 expression, cell proliferation, and apoptosis. In endometriosis, p38 MAPK activity was significantly higher in both eutopic and ectopic tissues during late proliferative and early secretory phases, and increased activity correlated with IL-8 expression (r=0.83, P<0.01) but not with apoptosis in vivo. In cultured endometriotic stromal cells, IL-1β and TNF-α activated p38 MAPK and inhibition of p38 MAPK blocked IL-1β- and TNF-α-induced IL-8 and MCP-1 secretion, without affecting endometriotic cell survival. A key caveat is that the assessment of cell survival in vitro used pharmacologic inhibition and specific assays, which may not capture all in vivo survival mechanisms. This paper is centrally about endometriosis — it identifies p38 MAPK as a driver of the inflammatory milieu via IL-8/MCP-1 regulation, rather than through effects on cell survival.

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Condition tags

endometriosis

MeSH descriptors

Cell Survival Endometriosis Endometrium Inflammation p38 Mitogen-Activated Protein Kinases Adult Apoptosis Apoptosis Cell Survival Chemokine CCL2 Chemokine CCL2 Endometriosis Endometrium Female Humans Inflammation Interleukin-1beta Interleukin-1beta Interleukin-8 Interleukin-8

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