Decreased Bcl-6 and increased Blimp-1 in the peritoneal cavity of patients with endometriosis

Seung Geun Yeo, Yeol SG, S G Yeol, Y S Won, Won YS, Yong Sung Won, Kim YI, Young Tae Kim, Y I Kim, Lee JW, J. W. Lee, Jae Woo Lee, Y J Choi, Choi YJ, Yoon Ji Choi, D C Park, DC Park, Park DC
Clinical and experimental obstetrics & gynecology · 2015 · vol. 42(2) , pp. 156–160 · doi:10.12891/ceog1818.2015 · PMID:26054109 · W606871765
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This study found significantly decreased Bcl-6 and increased Blimp-1 mRNA levels in the peritoneal cavity of endometriosis patients compared to controls, with correlations to immune factors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The study investigated peritoneal fluid from 98 women—46 with endometriosis and 52 with benign tumors—to assess expression of inflammatory cytokines IL-1β and TNF-α, transcription factors Bcl-6 and Blimp-1, concentrations of immunoglobulins IgG and IgA, and correlations among these measures. IL-1β and TNF-α mRNAs and IgG/IgA levels were higher in the endometriosis group, but these differences were not statistically significant, whereas Bcl-6 mRNA was significantly lower and Blimp-1 mRNA significantly higher in endometriosis. The authors reported significant correlations among transcriptional factors, immunoglobulins, and cytokines (p < 0.05). The paper concludes that altered proinflammatory cytokine and transcription-factor expression may be linked to increased IgG and IgA in endometriosis. This paper is centrally about endometriosis—focusing on how peritoneal cytokines, immunoglobulins, and the Bcl-6/Blimp-1 regulatory axis differ in patients with endometriosis.

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Abstract

PURPOSE OF INVESTIGATION: The authors investigated the expression patterns of interleukin (IL)-lβ and tumor necrosis factor (TNF)-α, cytokines associated with peritoneal inflammatory reactions, and of B cell leukemia lymphoma (Bcl)-6 and B lymphocyte inducer of maturation program (Blimp)-1, transcriptional factors associated with immunoglobulin (Ig) production; the concentrations of Igs, and their correlation, in patients with and without endometriosis. MATERIALS AND METHODS: The authors analyzed the peritoneal fluid of 98 patients, 46 with endometriosis, and 52 with benign tumors. RESULTS: IL-1 and TNF-α mRNAs and IgG and IgA concentrations were higher in the endometriosis group, but the differences were not statistically significant. However, Bcl-6 mRNA level was significantly lower and Blimp-1 mRNA level was significantly higher in the endometriosis group with significant correlations among transcriptional factors, Igs, and cytokines (p < 0.05). CONCLUSION: Peritoneal immune responses in patients with endometriosis may be due to increased IgG and IgA concentrations, as well as to changes in expression of proinflammatory cytokines and transcriptional factors.
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Abstract

Purpose of investigation: The authors investigated the expression patterns of interleukin (IL)-1β and tumor necrosis factor (TNF)-α, cytokines associated with peritoneal inflammatory reactions, and of B cell leukemia lymphoma (Bcl)-6 and B lymphocyte inducer of maturation program (Blimp)-1, transcriptional factors associated with immunoglobulin (Ig) production; the concentrations of Igs, and their correlation, in patients with and without endometriosis. Materials and Methods: The authors analyzed the peritoneal fluid of 98 patients, 46 with endometriosis, and 52 with benign tumors. Results: IL-1β and TNF-α mRNAs and IgG and IgA concentrations were higher in the endometriosis group, but the differences were not statistically significant. However, Bcl-6 mRNA level was significantly lower and Blimp-1 mRNA level was significantly higher in the endometriosis group with significant correlations among transcriptional factors, Igs, and cytokines (p < 0.05). Conclusion: Peritoneal immune responses in patients with endometriosis may be due to increased IgG and IgA concentrations, as well as to changes in expression of proinflammatory cytokines and transcriptional factors.

Keywords

- Bcl-6 - Blimp-1 - Immunoglobulin - Endometriosis

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid DNA-Binding Proteins Endometriosis Repressor Proteins Adult Ascitic Fluid Cytokines DNA-Binding Proteins Endometriosis Endometriosis Female Humans Immunoglobulin A Immunoglobulin A Immunoglobulin G Immunoglobulin G Interleukin-1beta Interleukin-1beta Male Middle Aged

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