Decreased Bcl-6 and increased Blimp-1 in the peritoneal cavity of patients with endometriosis

S G Yeol, Seung Geun Yeo, Y S Won, Yong Sung Won, Y I Kim, Young Tae Kim, J W Lee, Jae Woo Lee, Y J Choi, Yoon Ji Choi, D C Park
Clinical and experimental obstetrics & gynecology · 2015 · vol. 42(2) , pp. 156–160 · doi:10.12891/ceog1818.2015 · PMID:26054109 · W606871765
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This study found significantly decreased Bcl-6 and increased Blimp-1 mRNA levels in the peritoneal cavity of endometriosis patients compared to controls, with correlations to immune factors.

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Abstract

PURPOSE OF INVESTIGATION: The authors investigated the expression patterns of interleukin (IL)-lβ and tumor necrosis factor (TNF)-α, cytokines associated with peritoneal inflammatory reactions, and of B cell leukemia lymphoma (Bcl)-6 and B lymphocyte inducer of maturation program (Blimp)-1, transcriptional factors associated with immunoglobulin (Ig) production; the concentrations of Igs, and their correlation, in patients with and without endometriosis. MATERIALS AND METHODS: The authors analyzed the peritoneal fluid of 98 patients, 46 with endometriosis, and 52 with benign tumors. RESULTS: IL-1 and TNF-α mRNAs and IgG and IgA concentrations were higher in the endometriosis group, but the differences were not statistically significant. However, Bcl-6 mRNA level was significantly lower and Blimp-1 mRNA level was significantly higher in the endometriosis group with significant correlations among transcriptional factors, Igs, and cytokines (p < 0.05). CONCLUSION: Peritoneal immune responses in patients with endometriosis may be due to increased IgG and IgA concentrations, as well as to changes in expression of proinflammatory cytokines and transcriptional factors.
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Abstract

Purpose of investigation: The authors investigated the expression patterns of interleukin (IL)-1β and tumor necrosis factor (TNF)-α, cytokines associated with peritoneal inflammatory reactions, and of B cell leukemia lymphoma (Bcl)-6 and B lymphocyte inducer of maturation program (Blimp)-1, transcriptional factors associated with immunoglobulin (Ig) production; the concentrations of Igs, and their correlation, in patients with and without endometriosis. Materials and Methods: The authors analyzed the peritoneal fluid of 98 patients, 46 with endometriosis, and 52 with benign tumors. Results: IL-1β and TNF-α mRNAs and IgG and IgA concentrations were higher in the endometriosis group, but the differences were not statistically significant. However, Bcl-6 mRNA level was significantly lower and Blimp-1 mRNA level was significantly higher in the endometriosis group with significant correlations among transcriptional factors, Igs, and cytokines (p < 0.05). Conclusion: Peritoneal immune responses in patients with endometriosis may be due to increased IgG and IgA concentrations, as well as to changes in expression of proinflammatory cytokines and transcriptional factors.

Keywords

- Bcl-6 - Blimp-1 - Immunoglobulin - Endometriosis

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid DNA-Binding Proteins Endometriosis Repressor Proteins Adult Ascitic Fluid Cytokines DNA-Binding Proteins Endometriosis Endometriosis Female Humans Immunoglobulin A Immunoglobulin A Immunoglobulin G Immunoglobulin G Interleukin-1beta Interleukin-1beta Male Middle Aged

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