The role of the immune system in the pathogenesis of endometriosis

Оlga O. Kabanova, Arika G. Melkumian, Krechetova L.V. Krechetova, Irina V. Menzhinskay, С. В. Павлович
In: Gynecology · 2021 · vol. 23(6) , pp. 485–492 · doi:10.26442/20795696.2021.6.200966 · W4210686115
article OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review analyzes data showing that abnormal inflammatory responses and immune system dysregulation significantly contribute to the development and persistence of endometriosis.

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Abstract

The review presents a critical analysis of data on the role of immune factors in the pathogenesis of endometriosis. The research results accumulated by now convincingly demonstrate that an abnormal subclinical inflammatory response and disorders in the immune control system play a significant role in the onset, progression and persistence of endometriosis. In spite of the fact that many studies are concentrates on particular components of immune disorders in the pathogenesis of endometriosis, there is still no overall picture summarizing these data. Further research is needed to find immunological parameters that can be used as markers for clinical use in non-invasive diagnosis of this disease. The search for specific immune markers that could be used for target immunotherapy of endometriosis also remains relevant.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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