Serum Level of IL-10 Is Increased in Patients with Endometriosis, and IL-10 Promotes the Growth of Lesions in a Murine Model

Jau-Ling Suen, Jau‐Ling Suen, Chang Y, Yu Chang, Pu-Rong Chiu, Chiu PR, Tsung-Hua Hsieh, Tsung‐Hua Hsieh, Hsieh TH, Edward Hsi, Hsi E, Yu-Chieh Chen, Chen YC, Yu‐Chieh Chen, Yufang Chen, Chen YF, Yu-Fang Chen, Tsai EM, Eing-Mei Tsai, Eing‐Mei Tsai
The American Journal of Pathology · 2013 · vol. 184(2) , pp. 464–471 · doi:10.1016/j.ajpath.2013.10.023 · PMID:24326257 · W2090330334
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Serum IL-10 levels are elevated in endometriosis patients, and this cytokine promotes lesion growth in a murine model.

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Abstract

Immune dysregulation may be involved in the development of endometriosis. The anti-inflammatory cytokine IL-10 plays an important role in eliminating unwanted cells and cellular debris in a silent way. We investigated the modulatory role of IL-10 in the development of endometriosis. We observed that the serum level of IL-10 in patients with endometriosis was significantly higher than that in healthy subjects or in control subjects with other gynecological disease. Monocyte-derived dendritic cells acquired from male donors and subsequently conditioned with serum from women with endometriosis exhibited a tolerogenic phenotype, including increased IL-10 production, lower IL-12 secretion, and down-regulation of CD86 and HLA-DR molecules. Depletion of IL-10 activity in a C57BL/6 mouse model of surgically induced endometriosis significantly decreased the size of endometrial lesions. In contrast, IL-10 administration promoted the growth of endometrial lesions in this model. In addition, infiltrated plasmacytoid dendritic cells were the primary IL-10-secreting immune cells in endometrial lesions. Our findings suggest that IL-10 may suppress immunity against endometrial implants, contributing to development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Interleukin-10 Adult Animals Antibodies, Blocking Antibodies, Blocking Case-Control Studies Cells, Cultured Culture Media, Conditioned Culture Media, Conditioned Demography Dendritic Cells Dendritic Cells Dendritic Cells Disease Models, Animal Endometriosis Female Humans Immune Tolerance

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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