Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses

Zhang Z, Zhe Zhang, Ding Y, Yumei Ding, Junjie Li, Li J, Shan-Yu Su, Su S, Shan Su
Histology and histopathology · 2023 · vol. 38(3) , pp. 329–337 · doi:10.14670/hh-18-523 · PMID:36156768 · W4297250646
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found that CMKLR1 is up-regulated in endometriosis tissues and peritoneal fluid, correlating with inflammatory markers and exacerbating inflammation in human endometrial stromal cells.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This study investigated whether the chemerin chemokine-like receptor 1 (CMKLR1) contributes to inflammatory responses in endometriosis by analyzing 60 patients with endometriosis and 50 healthy controls. Using ELISA, qRT-PCR, and immunohistochemistry on peritoneal fluid and endometrial tissues, the authors found CMKLR1 was significantly up-regulated in endometriosis, and CMKLR1 levels positively correlated with pro-inflammatory cytokines and chemokines including IL-6, MCP-1, and TNF-α. In human endometrial stromal cells, chemerin exposure increased CMKLR1 expression and aggravated inflammatory responses. The paper links CMKLR1 up-regulation to inflammatory signaling in endometriosis, stating that CMKLR1 promotes inflammatory responses in this condition. This paper is centrally about endometriosis — it focuses on CMKLR1 up-regulation and its relationship with inflammatory responses in patients and in cultured endometrial stromal cells.

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Abstract

Inflammation plays a critical role in the pathogenesis of endometriosis. We aimed to study the proinflammatory effect of Chemerin chemokine-like receptor 1 (CMKLR1) in patients with endometriosis. Sixty patients with endometriosis and 50 healthy controls were recruited in this study for the collection of endometrial samples and peritoneal fluid. The expression levels of CMKLR1, IL-6, MCP-1, and TNF-α in peritoneal fluid and endometrial tissues were detected by ELISA, qRT-PCR, and immunohistochemical staining. Human endometrial stromal cells (HESCs) were used to measure the Chemerin-induced CMKLR1 activation and inflammatory responses. CMKLR1 level was significantly up-regulated in peritoneal fluid and endometrial tissues in patients with endometriosis. Interestingly, CMKLR1 overexpression positively correlated with pro-inflammatory cytokines and chemokine in both peritoneal fluid and ectopic endometrium. Chemerin treatment increased the expression of CMKLR1, and aggravated inflammatory responses in HESCs. CMKLR1 is up-regulated in peritoneal fluid and endometrial tissues, and promotes the inflammatory responses in of endometriosis.
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Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses Zhe Zhang1, Yumei Ding1, Junjie Li2 and Shan Su1 1Department of Gynecology and 2Department of Anesthesiology, Zibo Central Hospital, Zibo, Shandong, China Corresponding Author: Junjie Li, Department of Anesthesiology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo 255036, Shandong, China. e-mail: [email protected] Summary. Inflammation plays a critical role in the pathogenesis of endometriosis. We aimed to study the proinflammatory effect of Chemerin chemokine-like receptor 1 (CMKLR1) in patients with endometriosis. Sixty patients with endometriosis and 50 healthy controls were recruited in this study for the collection of endometrial samples and peritoneal fluid. The expression levels of CMKLR1, IL-6, MCP-1, and TNF-α in peritoneal fluid and endometrial tissues were detected by ELISA, qRT-PCR, and immunohisto-chemical staining. Human endometrial stromal cells (HESCs) were used to measure the Chemerin-induced CMKLR1 activation and inflammatory responses. CMKLR1 level was significantly up-regulated in peritoneal fluid and endometrial tissues in patients with endometriosis. Interestingly, CMKLR1 overexpression positively correlated with pro-inflammatory cytokines and chemokine in both peritoneal fluid and ectopic endometrium. Chemerin treatment increased the expression of CMKLR1, and aggravated inflammatory responses in HESCs. CMKLR1 is up-regulated in peritoneal fluid and endometrial tissues, and promotes the inflammatory responses in of endometriosis. Histol Histopathol 38, 329-337 (2023) Key words: CMKLR1, Endometriosis, Inflammatory responses, Chemerin DOI: 10.14670/HH-18-523 | �The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License. |

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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