Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6

Francisco Carmona, Chapron C, Charles Chapron, Maria Ángeles Martínez‐Zamora, Martínez-Zamora MÁ, María-Ángeles Martínez-Zamora, Santulli P, Pietro Santulli, Piétro Santulli, Aintzane Rabanal, Rabanal A, Martínez-Florensa M, Mario Martínez-Florensa, Mario Martínez‐Florensa, Francisco Lozano, Balasch J, Juan Balasch
Journal of Reproductive Immunology · 2012 · vol. 95(1-2) , pp. 80–86 · doi:10.1016/j.jri.2012.06.001 · PMID:22819248 · W2124919654
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Ovarian endometriomas, but not deep infiltrating endometriosis, were associated with elevated serum concentrations of interleukin-8 and interleukin-6.

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Abstract

Cytokines, and specifically interleukin 6 (IL-6) and interleukin 8 (IL-8), have been associated with the pathogenesis of endometriosis. We studied serum concentrations of IL-6 and IL-8 in patients with deep infiltrating endometriosis (DIE) or ovarian endometriomas (OE), but no other forms of associated endometriosis disease type. We carried out a case-control study including 19 patients with OE alone (OE group), 14 patients with DIE alone (DIE group) and 24 healthy patients without endometriosis (C group). Serum concentrations of IL-6 and IL-8 were measured in the three groups of patients. Serum levels of both IL-6 and IL-8 were significantly higher in the OE group. A high positive correlation was found between serum IL-6 and IL-8 levels in the OE group but not in the DIE and C groups. Serum IL-8 alone achieved the highest predictive value of the presence of OE (adjusted OR: 1.44; sensitivity: 78.2%; specificity: 76.2%). The combination of IL-6 and IL-8 levels did not significantly improve the discrimination between subjects with OE and those with DIE over that of IL-8. OE but not DIE are associated with increased serum levels of IL-6 and IL-8, and thus these may become useful tools for discriminating OE alone from DIE.

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Condition tags

endometriosisdie_deep_infiltratingendometrioma

MeSH descriptors

Endometriosis Interleukin-6 Interleukin-8 Ovarian Diseases Adolescent Adult Case-Control Studies Endometriosis Endometriosis Endometriosis Female Humans Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 Ovarian Diseases Ovarian Diseases Ovarian Diseases

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