Cytokine profile features in women with reproductive disorders exposed to excessive environmental contamination with hydroxybenzene

Olga A. Kazakova, Оleg V. Dolgikh
In: Medical Immunology (Russia) · 2021 · vol. 23(1) , pp. 173–178 · doi:10.15789/1563-0625-cpf-2054 · W3133778602
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This study found that women with endometriosis exposed to excess hydroxybenzene showed increased IL-10 and altered IL-8 and IL-1β levels, suggesting hydroxybenzene contributes to reproductive disorders via cytokine imbalance.

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This paper examines cytokine profile features in women with reproductive disorders who were exposed to excessive environmental contamination with hydroxybenzene, using an immunological profiling approach to characterize differences in cytokine levels. The key finding is that hydroxybenzene exposure is associated with specific alterations in the cytokine profile among these women, reflecting an immune response pattern relevant to reproductive disorders. The study’s main limitation is that details needed to fully interpret generalizability and causal inference are not explicit in the provided excerpt (e.g., extent of exposure assessment, sample size, and study design specifics). The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Excessive activity of cytokines, as well as their deficiency, promote a regulatory imbalance of immune system, which may cause persistent inflammation and, as a consequence, loss of pregnancy. The purpose of our work was to study the role of cytokine expression in the development of endometriosis in women exposed to excessive environmental contamination with hydroxybenzene. The study involved 106 women of reproductive age, divided into 4 groups according to two criteria: the presence or absence of reproductive disorders (endometriosis), as well as levels of blood contamination with hydroxybenzene compared to the reference ranges. The groups of women were comparable in age, ethnicity, and social status. The level of phenol in blood was measured by gas chromatography, and the cytokine levels were determined by enzyme immunoassay. The use of parametric and nonparametric statistical criteria as well as adjustments for multiple Bonferoni comparisons, allowed us to establish significant differences between the groups, according to the levels of IL-1β, IL-8, IL-10. The expression of interleukin 8 (IL-8) in women with endometriosis was found to be significantly higher than in healthy ones. At the same time, the observed features of IL-8, interleukin 1β (IL-1β) expression correlate with the overproduction of interleukin 10 (IL-10) associated with excessive contamination of bio-environments with hydroxybenzene. The results of using non-parametric correlation analysis of the Spearman data revealed a positive correlation between IL-10 production and hydroxybenzene levels in the blood, as well as inverse relationship between IL-10 and IL-8 expression. Thus, evidence has been obtained of the involvement of exogenous estrogen hydroxybenzene in development of reproductive disorders, probably, formed under active participation of increased anti-inflammatory IL-10 cytokine, which, by antagonism to proinflammatory mediators (e.g., IL-8), seems to promote apparent transition from acute phase of endometriosis to chronic disorder, thus reducing the reproductive potential of women. It is known that IL-8 expression significantly correlates with development of endometriosis, but excessive phenol exposure may increase the anti-inflammatory IL-10 expression, thereby suppressing the activity of IL-8. Suppressed activity of proinflammatory cytokines by phenol may lead to chronic inflammation and impaired reproductive functions.
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Особенности цитокинового профиля женщин с репродуктивными нарушениями в условиях избыточной контаминации биосред гидроксибензолом https://doi.org/10.15789/1563-0625-CPF-2054 Аннотация Об авторах О. А. КазаковаРоссия Казакова Ольга Алексеевна – младший научный сотрудник лаборатории иммуногенетики 614012, г. Пермь, ул. Веры Засулич, 42а, кв. 74 О. В. Долгих Россия д.м.н., профессор, заведующий отделом иммунобиологических методов диагностики 614012, г. Пермь, ул. Веры Засулич, 42а, кв. 74 Список литературы 1. Akdis C.A., Hellings P.W., Agache I. Global atlas of allergic rhinitis and chronic rhinosinusitis. Zurich, Switzerland: European Academy of Allergy and Clinical Immunology, 2015. 422 р. 2. Akselrod S. Components of heart rate variability: basis studies. Heart Rate Variability, 1995, № 12, pp. 147-163. 3. Berezhansky P.V., Berezhanskaya Yu.S. Modern features of the pathogenesis of bronchial asthma and the contribution of microcirculation in the development of chronic allergic pathology. Materials of international scientific-practical conference “Modern strategies and technologies for the prevention, diagnosis, treatment and rehabilitation of patients of different ages suffering from chronic non-infectious whitening”, 2018, pp. 113-126. 4. Berezhansky P.V., Turchaninov S.O. A method for diagnosing the state of the capillary bed in various diseases in children. Acoustic-optical and radar methods for measuring and processing information: materials of the 12th International Scientific and Technical Conference, 2019, pp.104-106. 5. Korzheva I.Iu., Iakovlev V.N., Mumladze R. B., Rozikov Iu.Sh., Duvanskiĭ V.A. Blood microcirculation disorder in patients with microcirculation study. Allergy Rhinol. (Providence), 2018, Vol. 9, pp. 1-9. 6. Lee E., Hong S.J. Phenotypes of allergic diseases in children and their application in clinical situations. Korean J. Pediatr., 2019, Vol. 62, no. 9, pp. 325-333. 7. Ozsutcu M., Ozkaya E., Demir A., Erenberk U., Sogut A., Dundaroz R. Pupillometric assessment of autonomic nervous system in children with allergic rhinitis. Med. Princ. Pract., 2013, Vol. 22, no. 5, pp. 444-448. 8. Roberts G., Xatzipsalti M., Borrego LM, Custovic A., Halken S., Hellings P.W., Papadopoulos N.G., Rotiroti G., Scadding G., Timmermans F., Valovirta E. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy, 2013, Vol. 68, pp. 1102-1116. 9. Tataurshchikova N. Rational pharmacotherapy in cases of mucosal immunity pathologies among patients suffering from allergic rhinitis. Bulletin of Otorhinolaryngology, 2013, no. 5, pp. 93-97. (In Russ.) 10. Tataurschikova N.S. Features of allergic inflammation in the assessment of phenotypes of allergic rhinitis. Farmateka, 2018, no. 1, pp. 12-15. (In Russ.) 11. Undem B.J., Taylor-Clark T. Mechanisms underlying the neuronal-based symptoms of allergy. J. Allergy Clin. Immunol., 2014, Vol. 6, pp.1521-1534. 12. Wiernsperger N., Rapin J.R. Microvascular diseases: is a new era coming? Cardiovasc. Hematol. Agents Med. Chem., 2012, Vol. 6, pp. 167-183. Рецензия Для цитирования: Казакова О.А., Долгих О.В. Особенности цитокинового профиля женщин с репродуктивными нарушениями в условиях избыточной контаминации биосред гидроксибензолом. Медицинская иммунология. 2021;23(1):173-178. https://doi.org/10.15789/1563-0625-CPF-2054 For citation: Kazakova O.A., Dolgikh O.V. Cytokine profile features in women with reproductive disorders exposed to excessive environmental contamination with hydroxybenzene. Medical Immunology (Russia). 2021;23(1):173-178. (In Russ.) https://doi.org/10.15789/1563-0625-CPF-2054 JATS XML

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