Endometriosis-associated changes in serum levels of interferons and chemokines

Măluțan AM, Andrei Mihai Măluțan, Andrei Mihai Măluţan, Tudor Drugan, Răzvan Ciortea, Ciortea R, Carmen Elena Bucuri, Carmen Bucuri, Bucuri C, Rada MP, Maria Patricia Rada, Mihu D, Dan Mihu
Turkish journal of medical sciences · 2017 · vol. 47(1) , pp. 115–122 · doi:10.3906/sag-1507-185 · PMID:28263477 · W2593567543
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This study found that women with endometriosis have higher serum levels of IFN-γ, MCP-1, and IL-8, and lower levels of IP-10 and eotaxin compared to healthy controls.

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The study evaluated serum concentrations of interferons and multiple chemokines in 160 women, comparing those with diagnosed endometriosis to healthy controls. Using Human Multiplex Cytokine Panels, the authors found significantly higher serum levels of IFN-γ, MCP-1, and IL-8 in the endometriosis group, while IP-10 and eotaxin were significantly lower than in controls. The paper’s caveat is that it reports circulating biomarker differences without additional detail on confounders or a mechanistic explanation for the altered immune activity. This paper is centrally about endometriosis — it specifically measures and contrasts serum interferon and chemokine levels in women with endometriosis versus healthy controls.

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Abstract

BACKGROUND/AIM: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. MATERIALS AND METHODS: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-γ, MCP-1, and IL-8, and lower serum levels of IP-10 and eotaxin, indicating unbalanced immune activity in endometriosis.
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Abstract

Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-γ, MCP-1, and IL-8, and lower serum levels of IP-10 and eotaxin, indicating unbalanced immune activity in endometriosis. DOI 10.3906/sag-1507-185

Keywords

Chemokine, inflammation, endometriosis, interferon First Page 115 Last Page 122 Recommended Citation MALUTAN, A. M, DRUGAN, T, CIORTEA, R, BUCURI, C, RADA, M. P, & MIHU, D (2017). Endometriosis-associated changes in serum levels of interferons and chemokines. Turkish Journal of Medical Sciences 47 (1): 115-122. https://doi.org/10.3906/sag-1507-185

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Condition tags

endometriosis

MeSH descriptors

Chemokines Endometriosis Endometriosis Interferons Adolescent Adult Case-Control Studies Chemokines Endometriosis Female Humans Interferons Young Adult

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