Concentrations of Interferon‐γ‐Induced Protein‐10 (IP‐10), an Antiangiogenic Substance, are Decreased in Peritoneal Fluid of Women with Advanced Endometriosis

Osamu Yoshino, Yoshino O, Yutaka Osuga, Osuga Y, Kaori Koga, Yasushi Hirota, Tsutsumi O, Osamu Tsutsumi, Tetsu Yano, Yano T, Morita Y, Yutaka Morita, Momoeda M, Mikio Momoeda, Fujiwara T, Toshihiro Fujiwara, Kugu K, Koji Kugu, Taketani Y, Yuji Taketani
American journal of reproductive immunology (New York, N.Y. : 1989) · 2003 · vol. 50(1) , pp. 60–65 · doi:10.1034/j.1600-0897.2003.00037.x · PMID:14506929 · W2118924004
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Interferon-gamma-induced protein-10 (IP-10) concentrations were significantly lower in the peritoneal fluid of women with advanced endometriosis compared to those with early stages of the disease.

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Abstract

PROBLEM: To assess whether interferon-gamma-induced protein-10 (IP-10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis. METHOD OF STUDY: A total of 120 patients undergoing laparoscopy for pain and/or infertility were recruited, and peritoneal fluid (PF) and bone marrow derived cells in PF were collected. Concentrations of IP-10 in PF were measured with a specific enzyme-linked immunosorbent assay. Expression of IP-10 and IP-10 receptor, CXCR3, in bone marrow derived cells in PF, peritoneum and endometriotic cells was analyzed by reverse transcription-polymerase chain reaction. RESULTS: All of the PF samples examined contained detectable concentrations of IP-10. In women with advanced stages of endometriosis, IP-10 concentrations in PF were significantly lower than those of women in early stages (P = 0.02). The IP-10 concentrations in women with advanced endometriosis also appeared to be lower than those without endometriosis although the difference was statistically marginal (P = 0.06). The expression of both IP-10 and CXCR3 was clearly detected in the bone marrow derived cells in PF, peritoneum and endometriotic stromal cells. CONCLUSIONS: Decreased concentrations of IP-10 in PF from women with advanced stages of endometriosis may imply that the peritoneal environment of these women is permissive to the development of the disease by enhancing angiogenesis and/or modulating inflammatory/immunological responses.

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Chemokines, CXC Endometriosis Adult Ascitic Fluid Chemokine CXCL10 Chemokines, CXC Chemokines, CXC Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Peritoneal Cavity Peritoneal Cavity Receptors, Chemokine Receptors, Chemokine Receptors, Chemokine Receptors, CXCR3 Reverse Transcriptase Polymerase Chain Reaction

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