Concentration of Adiponectin in Peritoneal Fluid is Decreased in Women with Endometriosis

Yuri Takemura, Takemura Y, Osuga Y, Yutaka Osuga, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Osamu Yoshino, Yoshino O, Yasushi Hirota, Morimoto C, Chieko Morimoto, Tetsu Yano, Yano T, Taketani Y, Yuji Taketani
American journal of reproductive immunology (New York, N.Y. : 1989) · 2005 · vol. 54(4) , pp. 217–221 · doi:10.1111/j.1600-0897.2005.00300.x · PMID:16135012 · W1984268820
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Adiponectin concentrations were significantly lower in the peritoneal fluid of women with endometriosis, particularly in advanced stages, suggesting it may act as an anti-endometriotic factor.

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Abstract

PROBLEM: Adiponectin is a novel adipocytokine of extreme importance for the metabolism. Recent studies have indicated that adiponectin suppresses inflammation, angiogenesis, and fibrosis, which are central pathogenic factors for endometriosis. We addressed the possibility that adiponectin is implicated in endometriosis. METHOD OF STUDY: We measured concentrations of adiponectin in peritoneal fluid (PF) of women with (n = 54) or without (n = 26) endometriosis using specific enzyme-linked immunosorbent assay. RESULTS: Adiponectin concentrations in PF of women with endometriosis were significantly lower than those of women without endometriosis. With respect to the stages of the disease, the concentrations of adiponectin in women with stage III/IV endometriosis were significantly lower compared to those in women without endometriosis and with stage I/II endometriosis. Body mass index were comparable among the groups. CONCLUSIONS: These findings imply that adiponectin may be an anti-endometriotic factor, possibly due to its anti-inflammatory, anti-angiogenic, and anti-fibrotic properties.

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Condition tags

endometriosis

MeSH descriptors

Adiponectin Ascitic Fluid Endometriosis Adiponectin Adiponectin Adult Ascitic Fluid Body Mass Index Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female

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