Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis

Pasquale Florio; Serena Pinzauti; Aldo Altomare; Stefano Luisi; Pietro Litta; Felice Petraglia

doi:10.5301/je.2009.2293

Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis

Pasquale Florio, Serena Pinzauti, Aldo Altomare, Stefano Luisi, Pietro Litta, Felice Petraglia

In: Journal of Endometriosis and Pelvic Pain Disorders · 2009 · vol. 1(2) , pp. 79–93 · doi:10.5301/je.2009.2293 · W2172579291

article OA: closed CC0 ⤵ 2 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the expression and role of peptides, proteins, and growth factors in endometriosis pathogenesis.

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Abstract

Growing evidence is demonstrating that several peptides (corticotrophin-releasing factor, urocortins, ghrelin), proteins (leptin, adiponectin) and growth factors (vascular endothelial growth factor...

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endometriosis

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References (100)

Ablation of Leptin Signaling Disrupts the Establishment, Development, and Maintenance of Endometriosis-Like Lesions in a Murine Model via openalex
Activin A, Activin Receptor Type II, Nodal, and Cripto mRNA Are Expressed by Eutopic and Ectopic Endometrium in Women With Ovarian Endometriosis via openalex
Activin A increases invasiveness of endometrial cells in an in vitro model of human peritoneum via openalex
Activin‐A secretion is increased in the eutopic endometrium from women with essndometriosis via openalex
Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis via openalex
Angiongenesis: a new theory for endometriosis via openalex
Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis. via openalex
Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development via openalex
Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis via openalex
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions via openalex
Concentration of Adiponectin in Peritoneal Fluid is Decreased in Women with Endometriosis via openalex
Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis via openalex
Different Basic Fibroblast Growth Factor and Fibroblast Growth Factor-Antisense Expression in Eutopic Endometrial Stromal Cells Derived from Women with and without Endometriosis via openalex
Differential Expression of IGF‐I and IGF‐II in Eutopic and Ectopic Endometria of Women With Endometriosis and in Women Without Endometriosis via openalex
Dysregulated Expression of<i>ebaf</i>, a Novel Molecular Defect in the Endometria of Patients with Infertility<sup>1</sup> via openalex
Effects of chocolate cyst fluid on endometrioma cell growth in culture via openalex
Effects of peritoneal macrophages from patients with endometriosis on the proliferation of endometrial carcinoma cell line ECC-1 via openalex
Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis via openalex
Endocrine and Paracrine Regulation of Endometrial Angiogenesis via openalex
Environmental immune disruption: a comorbidity factor for reproduction? via openalex
Epidermal growth factor and basic fibroblast growth factor in peritoneal fluid of women with endometriosis via openalex
Epidermal growth factor in human endometrium: proliferative effects in culture and immunocytochemical localization in normal and endometriotic tissues via openalex
Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study via openalex
Expression and Mitogenic Effect of Fibroblast Growth Factor-9 in Human Endometriotic Implant Is Regulated by Aberrant Production of Estrogen via openalex
Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium via openalex
Expression of epidermal growth factor, fibroblast growth factor‐2, and platelet‐derived growth factor‐A in the eutopic endometrium of women with endometriosis via openalex
FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis via openalex
Fibroblast Growth Factor (FGF), Intracellular Adhesion Molecule (sICAM‐1) Level in Serum and Follicular Fluid of Infertile Women with Polycystic Ovarian Syndrome, Endometriosis and Tubal Damage, and their Effect on ICSI Outcome via openalex
High serum follistatin levels in women with ovarian endometriosis via openalex
Hormonal regulation of endometriotic cell growth in primary cell culture system via openalex
Hormone and growth factor signaling in endometrial renewal: Role of stem/progenitor cells via openalex
Identification of epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in surgically induced endometriosis in rats. via openalex
Immunohistochemical analysis of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue and endometrium via openalex
Immunohistochemical Study of Angiogenic Factors in Endometrium and Endometriosis via openalex
Increased expression of endoglin in the eutopic endometrium of women with endometriosis via openalex
Increased Insulin-like Growth Factor 1 Activity Can Rescue KLE Endometrial-like Cells from Apoptosis via openalex
Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation via openalex
Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis1 via openalex
Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin‐Releasing Hormone and Urocortin via openalex
Inhibitory effects of a novel aromatase inhibitor, YM511, on growth of endometrial explants and insulin-like growth factor-I gene expression in rats with experimental endometriosis via openalex
Insulin‐Like Growth Factor–1 Isoform mRNA Expression in Women with Endometriosis via openalex
Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via 5 1 integrin via openalex
Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and -3 in the follicular fluid of infertile patients with endometriosis via openalex
Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis via openalex
Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis via openalex
Leptin is not involved in the pathophysiology of endometriosis-related infertility via openalex
Levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis via openalex
Macrophage secretory products and sperm zona pellucida binding via openalex
Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis via openalex
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. via openalex
Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis via openalex
Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex
Quantitative analysis of epidermal growth factor receptor gene expression in endometriosis. via openalex
Reduced proliferation and cell adhesion in endometriosis via openalex
Serum adiponectin concentrations are decreased in women with endometriosis via openalex
Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice via openalex
Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. via openalex
T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis. via openalex
The actions of estradiol and epidermal growth factor in endometrial and endometriotic stroma in vitro via openalex
The effect of growth factors on the proliferation of human endometrial stromal cells in culture via openalex
The peritoneal environment in endometriosis via openalex
The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis via openalex
The vascular endothelial growth factor (VEGF) +405G>C 5′-untranslated region polymorphism and increased risk of endometriosis in South Indian women: a case control study via openalex
Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study via openalex
Urokinase‐Type Plasminogen Activator and Insulin‐Like Growth Factor‐Binding Protein 3 mRNA Expression in Endometriotic Lesions and Eutopic Endometrium via openalex
Vascular development in endometriosis via openalex
Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis via openalex
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex
W2168418300 via openalex
W2168583421 via openalex
W2337621246 via openalex
W2082729560 via openalex
W102776994 via openalex
W151780086 via openalex
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W1966257589 via openalex
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W1971692175 via openalex
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W1985014579 via openalex
W1985959551 via openalex
W1986758971 via openalex
W1989413102 via openalex
W1990692512 via openalex
W1992451410 via openalex
W1995609823 via openalex
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W2009900149 via openalex
W2011114098 via openalex
W2011977636 via openalex
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Cited by (2)

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[1] Ablation of Leptin Signaling Disrupts the Establishment, Development, and Maintenance of Endometriosis-Like Lesions in a Murine Model via openalex

[2] Activin A, Activin Receptor Type II, Nodal, and Cripto mRNA Are Expressed by Eutopic and Ectopic Endometrium in Women With Ovarian Endometriosis via openalex

[3] Activin A increases invasiveness of endometrial cells in an in vitro model of human peritoneum via openalex

[4] Activin‐A secretion is increased in the eutopic endometrium from women with essndometriosis via openalex

[5] Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis via openalex

[6] Angiongenesis: a new theory for endometriosis via openalex

[7] Association of protease activity against IGFBP-3 with peritoneal fluid mitogens: possible implications for the ectopic growth of endometrial cells in women with endometriosis. via openalex

[8] Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development via openalex

[9] Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis via openalex

[10] Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions via openalex

[11] Concentration of Adiponectin in Peritoneal Fluid is Decreased in Women with Endometriosis via openalex

[12] Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis via openalex

[13] Different Basic Fibroblast Growth Factor and Fibroblast Growth Factor-Antisense Expression in Eutopic Endometrial Stromal Cells Derived from Women with and without Endometriosis via openalex

[14] Differential Expression of IGF‐I and IGF‐II in Eutopic and Ectopic Endometria of Women With Endometriosis and in Women Without Endometriosis via openalex

[15] Dysregulated Expression of<i>ebaf</i>, a Novel Molecular Defect in the Endometria of Patients with Infertility<sup>1</sup> via openalex

[16] Effects of chocolate cyst fluid on endometrioma cell growth in culture via openalex

[17] Effects of peritoneal macrophages from patients with endometriosis on the proliferation of endometrial carcinoma cell line ECC-1 via openalex

[18] Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis via openalex

[19] Endocrine and Paracrine Regulation of Endometrial Angiogenesis via openalex

[20] Environmental immune disruption: a comorbidity factor for reproduction? via openalex

[21] Epidermal growth factor and basic fibroblast growth factor in peritoneal fluid of women with endometriosis via openalex

[22] Epidermal growth factor in human endometrium: proliferative effects in culture and immunocytochemical localization in normal and endometriotic tissues via openalex

[23] Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study via openalex

[24] Expression and Mitogenic Effect of Fibroblast Growth Factor-9 in Human Endometriotic Implant Is Regulated by Aberrant Production of Estrogen via openalex

[25] Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium via openalex

[26] Expression of epidermal growth factor, fibroblast growth factor‐2, and platelet‐derived growth factor‐A in the eutopic endometrium of women with endometriosis via openalex

[27] FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis via openalex

[28] Fibroblast Growth Factor (FGF), Intracellular Adhesion Molecule (sICAM‐1) Level in Serum and Follicular Fluid of Infertile Women with Polycystic Ovarian Syndrome, Endometriosis and Tubal Damage, and their Effect on ICSI Outcome via openalex

[29] High serum follistatin levels in women with ovarian endometriosis via openalex

[30] Hormonal regulation of endometriotic cell growth in primary cell culture system via openalex

[31] Hormone and growth factor signaling in endometrial renewal: Role of stem/progenitor cells via openalex

[32] Identification of epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in surgically induced endometriosis in rats. via openalex

[33] Immunohistochemical analysis of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue and endometrium via openalex

[34] Immunohistochemical Study of Angiogenic Factors in Endometrium and Endometriosis via openalex

[35] Increased expression of endoglin in the eutopic endometrium of women with endometriosis via openalex

[36] Increased Insulin-like Growth Factor 1 Activity Can Rescue KLE Endometrial-like Cells from Apoptosis via openalex

[37] Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation via openalex

[38] Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis1 via openalex

[39] Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin‐Releasing Hormone and Urocortin via openalex

[40] Inhibitory effects of a novel aromatase inhibitor, YM511, on growth of endometrial explants and insulin-like growth factor-I gene expression in rats with experimental endometriosis via openalex

[41] Insulin‐Like Growth Factor–1 Isoform mRNA Expression in Women with Endometriosis via openalex

[42] Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via 5 1 integrin via openalex

[43] Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and -3 in the follicular fluid of infertile patients with endometriosis via openalex

[44] Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis via openalex

[45] Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis via openalex

[46] Leptin is not involved in the pathophysiology of endometriosis-related infertility via openalex

[47] Levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis via openalex

[48] Macrophage secretory products and sperm zona pellucida binding via openalex

[49] Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis via openalex

[50] Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. via openalex

[51] Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis via openalex

[52] Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex

[53] Quantitative analysis of epidermal growth factor receptor gene expression in endometriosis. via openalex

[54] Reduced proliferation and cell adhesion in endometriosis via openalex

[55] Serum adiponectin concentrations are decreased in women with endometriosis via openalex

[56] Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice via openalex

[57] Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. via openalex

[58] T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis. via openalex

[59] The actions of estradiol and epidermal growth factor in endometrial and endometriotic stroma in vitro via openalex

[60] The effect of growth factors on the proliferation of human endometrial stromal cells in culture via openalex

[61] The peritoneal environment in endometriosis via openalex

[62] The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis via openalex

[63] The vascular endothelial growth factor (VEGF) +405G>C 5′-untranslated region polymorphism and increased risk of endometriosis in South Indian women: a case control study via openalex

[64] Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study via openalex

[65] Urokinase‐Type Plasminogen Activator and Insulin‐Like Growth Factor‐Binding Protein 3 mRNA Expression in Endometriotic Lesions and Eutopic Endometrium via openalex

[66] Vascular development in endometriosis via openalex

[67] Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis via openalex

[68] Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex

[69] W2168418300 via openalex

[70] W2168583421 via openalex

[71] W2337621246 via openalex

[72] W2082729560 via openalex

[73] W102776994 via openalex

[74] W151780086 via openalex

[75] W1523805988 via openalex

[76] W1549920615 via openalex

[77] W1966257589 via openalex

[78] W1966486298 via openalex

[79] W1967490534 via openalex

[80] W1971692175 via openalex

[81] W1974450184 via openalex

[82] W1976454147 via openalex

[83] W1985014579 via openalex

[84] W1985959551 via openalex

[85] W1986758971 via openalex

[86] W1989413102 via openalex

[87] W1990692512 via openalex

[88] W1992451410 via openalex

[89] W1995609823 via openalex

[90] W2002687754 via openalex

[91] W2006948326 via openalex

[92] W2009900149 via openalex

[93] W2011114098 via openalex

[94] W2011977636 via openalex

[95] W2012973306 via openalex

[96] W2037472897 via openalex

[97] W2039201808 via openalex

[98] W2048166634 via openalex

[99] W2053096309 via openalex

[100] W2055926767 via openalex