Effects of chocolate cyst fluid on endometrioma cell growth in culture

Badawy Sz, Shawky Z.A. Badawy, S Z Badawy, Violeta Cuenca, Cuenca V, V Cuenca, Kumar S, Shubhra Kumar, S. Kumar, Holland J, J Holland, James A. Holland
Fertility and sterility · 1998 · vol. 70(5) , pp. 827–830 · doi:10.1016/s0015-0282(98)00303-3 · PMID:9806561 · W2169295630
article OA: bronze CC0 ⤵ 16 in-corpus citations
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This study investigated the impact of chocolate cyst fluid on endometrioma cell growth in cell culture, observing specific effects on their proliferation.

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Abstract

ObjectiveTo evaluate the effect of chocolate cyst fluid on the proliferation of cultured human endometrioma cells and to assay the concentration of transforming growth factor-B1 in this fluid.DesignControlled in vitro study.SettingDepartment of Obstetrics and Gynecology, State University of New York Health Science Center.Patient(s)Five women with ovarian endometriomas.Intervention(s)Endometrioma tissue and chocolate fluid from five different patients were entered in this study.Main outcome measure(s)Endometrioma cell proliferation in culture with and without chocolate cyst fluid.Result(s)Chocolate cyst fluid increased the proliferation of endometrioma cells compared with controls. Also, high concentrations of transforming growth factor-B1 were found in cysts' fluid.ConclusionsChocolate cyst fluid has a growth-enhancing effect on endometrioma cells. One promoting growth factor is transforming growth factor-B1.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cyst Fluid Endometriosis Ovarian Cysts Cell Count Cell Division Cell Division Cells, Cultured Cyst Fluid Cyst Fluid Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Ovarian Cysts Ovarian Cysts Transforming Growth Factor beta Transforming Growth Factor beta

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

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