The gametotoxic effects of the endometrioma content: insights from a parthenogenetic human model

Valentina Bolis
2018 · doi:10.26226/morressier.5af300af738ab10027aa94f6 · W4238089610
preprint OA: closed CC0 ⤵ 2 in-corpus citations
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Exposure of human oocytes to endometriotic fluid negatively impacted embryo morphology, primarily by increasing cellular fragmentation, though activation and overall development rates were unaffected.

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The provided text does not contain the paper’s actual scientific content (e.g., study design, experimental methods, results, or stated limitations), so a faithful biomedical summary cannot be generated from the available information. It appears to be titled “The gametotoxic effects of the endometrioma content: insights from a parthenogenetic human model,” suggesting a study of how substances from endometriomas affect gamete-related outcomes in a parthenogenetic human model, but the specific findings and caveats are not present in the excerpt. This paper is centrally about endometriosis — it focuses on gametotoxic effects of endometrioma content using a parthenogenetic human model.

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Abstract

The present randomized controlled in vitro study was designed to evaluate the effects of the exposure of human cryopreserved oocytes to endometriotic fluid.Twenty-three women aged 36 ± 4 years donated a total of 147 vitrified supernumerary metaphase-II oocytes.Warmed oocytes were randomly assigned to exposure to endometriotic fluid or unexposed control.Thereafter oocytes were parthenogenetically activated and cultured up to five days.The rate of activation on day 1 and the developmental rates on day 3 and day 5 did not significantly differ between the two groups.The rate of day 3 good quality parthenotes per oocyte was lower in exposed compared to unexposed oocytes, being 22% (13/60) and 41% (25/61), respectively.Moreover, in the exposed parthenotes, a significantly higher proportion of parthenotes failing to develop to the blastocyst stage showed cellular fragmentation (RR=0.64,95%CI: 1.04-2.57).Exposure of human oocytes to endometriotic fluid has a negative effect on the morphology of deriving embryos/parthenotes mainly due to an excess of cellular fragmentation.
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endometrioma

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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