High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata

Fasciani A, Alessandro Fasciani, A Fasciani, G D'Ambrogio, D'Ambrogio G, G Bocci, Guido Bocci, M Monti, Monti M, A. R. Genazzani, Genazzani AR, P. G. Artini, Artini PG
Molecular human reproduction · 2000 · vol. 6(1) , pp. 50–54 · doi:10.1093/molehr/6.1.50 · PMID:10611260 · W2162415686
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Ovarian endometriomata cyst fluids contained significantly higher concentrations of vascular endothelial growth factor and interleukin-8 than control follicular cysts, suggesting angiogenesis is involved in their development and maintenance.

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Abstract

Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) is a mitogen, morphogen and chemoactractant for endothelial cells and, in vivo, it is a powerful mediator for vessel permeability. Interleukin-8 (IL-8) is a chemoatractant for neutrophils and is a potent angiogenic factor. Women (n = 20) with ovarian endometriomata and 10 women with follicular cysts were enrolled in this study to investigate the role of VEGF and IL-8 in the development and maintenance of ovarian endometriomata. Cystic fluids were collected by laparoscopy, immediately centrifuged and stored until the enzyme-linked immunosorbent assays were performed. The VEGF and IL-8 concentrations were found to be significantly higher in the fluids of the ovarian endometriomata than in those of the follicular cysts of controls (P < 0.001 and P < 0.001 respectively); in addition, a significant inverse correlation between the VEGF cystic fluid concentrations and the diameter of the endometriotic adnexal masses was found (r = -0.56, P = 0.01). The evidence that the high concentrations of VEGF and IL-8 are present in the ovarian endometriomata indicates that angiogenesis could be a specific event both for the progression and maintenance of such cysts.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endothelial Growth Factors Interleukin-8 Lymphokines Adult CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometrium Endothelial Growth Factors Female Follicular Cyst Follicular Cyst Follicular Cyst Humans Interleukin-8 Lymphokines Retrospective Studies

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