Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis

Koki Shimura, Yosuke Tarumi, Maya Fujii, Kanae Ogawa, Eiko Maeda, Yukiko Tanaka, Hiroyuki Okimura, Hisashi Kataoka, Osamu Takaoka, Fumitake Ito, Akemi Koshiba, Khaleque N Khan, Khaleque Newaz Khan, Izumi Kusuki, Jo Kitawaki, Taisuke Mori
Reproductive sciences (Thousand Oaks, Calif.) · 2022 · vol. 30(4) , pp. 1094–1102 · doi:10.1007/s43032-022-01089-5 · PMID:36197633 · W4302027204
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Low nutrients increased proliferation and upregulated inflammatory and angiogenic factors, including PGC-1α, in endometriotic stromal cells compared to normal stromal cells.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The paper studied how a low-nutrient microenvironment affects stromal cells derived from ovarian endometrioma (OESCs) versus normal endometrium without endometriosis (NESCs), using nutrient depletion by culturing in Hank’s balanced salt solution. Under low-nutrient conditions, OESCs showed higher proliferation than NESCs, and low nutrient upregulated pro–endometriosis-related factors at the mRNA/protein level, including VEGF, interleukin-6 and -8, aromatase, Bcl-2, and the metabolic regulator PGC-1α, while downregulating BAX and increasing transcription of PI.3, PII, and exon II. Western blotting confirmed elevated VEGF and PGC-1α protein in OESCs under low nutrient, and PGC-1α increases were reduced when nutrient status was rescued. The limitation is that the work used cultured stromal cells and replicated “low nutrient” only by medium replacement, not in vivo nutrient gradients. This paper is centrally about endometriosis — it examines how low-nutrient conditions modulate inflammatory, angiogenic, anti-apoptotic, estrogen-related, and PGC-1α–linked metabolic pathways in ovarian endometrioma stromal cells.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

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