Yosuke Tarumi

Abstract Background Endometriosis-associated dysmenorrhea is commonly managed with hormonal therapies that suppress ovulation, limiting their use in women desiring fertility. Daidzein-rich isoflavone aglycones (DRIAs), a food-derived comp…

Endometriosis is defined as the presence of endometrium-like tissue outside the uterus and commonly affects pelvic organs. However, endometriotic lesions could occur at rare sites, including the bowel, bladder, abdominal wall, diaphragm, lu…

BACKGROUND: Endometriosis is increasingly recognized as a disorder of impaired reproductive immune tolerance rather than solely an endocrine disease. Although previous studies have reported inconsistent findings regarding the number of regu…

In brief: Progesterone resistance in endometriosis reduces the efficacy of progestin therapy. This study demonstrates that progesterone receptor membrane component 1 (PGRMC1) inhibition enhances progesterone responsiveness in endometriotic …

The pathology of endometriosis is associated with various inflammatory cytokines, including IL-1β, and recent studies have shown that spheroid cell cultures can be used to investigate the mechanisms of endometriosis-associated inflammation …

STUDY QUESTION: Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis? SUMMARY ANSWER: Adoptive transfer of Tregs suppresses the progression of endometriosis and reduces the levels of helper T (Th)-ce…

OBJECTIVE: Endometriosis is an estrogen-dependent disease wherein isoflavones interact with estrogen receptors. Daidzein-rich isoflavone aglycones (DRIAs) have been shown to inhibit cell proliferation and aromatase activity in vitro and in …

Partial cystectomy is often performed to treat bladder endometriosis. However, there are no reports of bladder rupture more than 10 years after cystectomy. A 55-year-old woman with a history of laparoscopic bilateral salpingo-oophorectomy a…

Menstrual blood, containing high iron levels, can undergo retrograde transport into the abdominal cavity. Excess iron causes oxidative stress and inflammation. Iron metabolism is regulated by hepcidin, and serum hepcidin levels are increase…

Although nutrient status plays an important role in cell metabolism, its significance in endometriosis is obscure. Herein, we investigated the effects of a low-nutrient microenvironment on endometriosis. Stromal cells (SCs) from ovarian end…

CONTEXT: Progesterone resistance including progesterone receptor (PR) deficiency contributes to the pathophysiology of endometriosis; however, whether the PR expression levels in ovarian endometrioma (OE) correlate with the postoperative re…

OBJECTIVE: Chronic inflammation in endometriosis is associated with increased risk of future cardiovascular disease; however, no studies have investigated the cardiovascular risk of women who have undergone hormonal therapy for endometriosi…

PROBLEM: Inflammation and immune responses play crucial roles in the development of endometriosis. Although interleukin-9 (IL-9) has a pro-inflammatory function in chronic inflammatory diseases, its function in endometriosis remains unknown…

Laparoscopic surgery has become the gold standard treatment for endometriosis. Surgical treatment of deep endometriosis with colorectal involvement is challenging. It requires complete surgical excision of lesions despite a high risk of com…

STUDY QUESTION: Is a peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α)-mediated pathway involved in the development of endometriosis? SUMMARY ANSWER: PGC-1α plays critical roles in inflammation and cell proliferation of …

•Malignant transformation of deep infiltrating endometriosis involving the bladder is quite rare.•We review eight relevant cases which have been reported.•This is the second case fulfilling Sampson and Scott criteria.