Transvaginal color Doppler sonography predicts ovarian interstitial fibrosis and microvascular injury in women with ovarian endometriotic cysts

Jun-Jun Qiu, Junjun Qiu, Man-Hua Liu, Manhua Liu, Zhongxin Zhang, Zhong-Xin Zhang, Li-Ping Chen, Liping Chen, Qi-Chang Yang, QI‐CHANG YANG, Hongbing Liu, Hong-Bing Liu
Acta obstetricia et gynecologica Scandinavica · 2012 · vol. 91(5) , pp. 605–612 · doi:10.1111/j.1600-0412.2012.01370.x · PMID:22313147 · W1695446382
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Transvaginal color Doppler sonography revealed decreased ovarian interstitial flow and increased resistance indices in women with endometriotic cysts, correlating with fibrosis and microvascular injury.

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Abstract

OBJECTIVE: To determine novel predictors of ovarian interstitial fibrosis and microvascular injury associated with ovarian endometriotic cysts (OECs). DESIGN: Case-control study. SETTING: The gynecology unit of an affiliated hospital in China. POPULATION: Women <40 years of age with OECs or benign ovarian tumors (controls). METHODS: Transvaginal color Doppler sonography was performed preoperatively to detect ovarian interstitial flow. Postoperatively, expressions of transforming growth factor-β1 (TGF-β1) and thrombospondin-1 (TSP-1), as well as microvessel density in ovarian interstitial, were analyzed using immunohistochemistry. MAIN OUTCOME AND MEASURES: Ovarian interstitial flow and expressions of TGF-β1, TSP-1, and microvessel density. RESULTS: Compared with controls, ovarian interstitial flow in the study group was decreased and arterial spectra indicated significantly higher resistance indices. Microvessel density was reduced, but TGF-β1 and TSP-1 were elevated in the study group. There was a positive correlation between TGF-β1 and TSP-1. There were negative correlations between TGF-β1 and microvessel density, and between TSP-1 and microvessel density. Microvessel density and resistance indices were negatively correlated, whereas the correlations of TGF-β1 and TSP-1 with resistance indices were positive. CONCLUSIONS: Resistance indices are consistent with pathological indices. Changes in resistance indices in ovaries with endometriosis are related to interstitial fibrosis and microvascular injury.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Microvessels Ovarian Cysts Ovary Ultrasonography, Doppler, Color Adult Case-Control Studies Endometriosis Female Fibrosis Fibrosis Humans Immunohistochemistry Microvessels Microvessels Ovarian Cysts Ovary Predictive Value of Tests Regional Blood Flow Regional Blood Flow

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