A new approach to the management of ovarian endometrioma to prevent tissue damage and recurrence

Giuseppe Benagiano; Felice Petraglia; Stephan Gordts; Ivo Brosens

doi:10.1016/j.rbmo.2016.03.001

A new approach to the management of ovarian endometrioma to prevent tissue damage and recurrence

Giuseppe Benagiano, Felice Petraglia, Stephan Gordts, Ivo Brosens

Reproductive biomedicine online · 2016 · vol. 32(6) , pp. 556–562 · doi:10.1016/j.rbmo.2016.03.001 · PMID:27037156 · W2294939295

review OA: bronze CC0 ⤵ 13 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper introduces a novel management strategy for ovarian endometriomas aimed at preventing both tissue damage and future recurrence.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Endometriosis Ovarian Diseases Adolescent Adult Animals Apoptosis Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometrium Endometrium Estrogens Estrogens Ethanol Ethanol Female Fertility Preservation Free Radicals Free Radicals Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (67)

A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study via openalex
Changes in cytokine levels of patients with ovarian endometriosis after treatment with gonadotropin-releasing hormone analogue, ultrasound-guided drainage, and intracystic recombinant interleukin-2 via openalex
Clinical value of components of the plasminogen activation system in ovarian cyst fluid. via openalex
Clinical value of components of the plasminogen activation system in ovarian cyst fluid. via openalex
Combined ultrasonographically guided drainage and methotrexate administration for treatment of endometriotic cysts via openalex
Development of a miniature, low-dose, frameless intrauterine levonorgestrel-releasing system for contraception and treatment: a review of initial clinical experience via openalex
Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles via openalex
Do endometriomas induce an inflammatory reaction in nearby follicles? via openalex
Effectiveness of ultrasound-guided aspiration and sclerotherapy with 95% ethanol for treatment of recurrent ovarian endometriomas via openalex
Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas via openalex
Exploring the Relationship between Endometriomas and Infertility via openalex
Expression of cadherins and CD44 isoforms in ovarian endometrial cysts via openalex
Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay via openalex
GnRH Analogues, Transvaginal Ultrasound-Guided Drainage and Intracystic Injection of Recombinant Interleukin-2 in the Treatment of Endometriosis via openalex
High serum follistatin levels in women with ovarian endometriosis via openalex
Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis via openalex
Impact of ovarian endometrioma on assisted reproduction outcomes via openalex
Important Initiative Roles of CD44 and Tenascin in Sampson's Theory of the Pathogenesis and Development of Endometriosis via openalex
Infected endometrioma in pregnancy masquerading as acute appendicitis via openalex
In situ methotrexate injection after transvaginal ultrasound-guided aspiration of ovarian endometriomas: A randomized controlled trial via openalex
In situ methotrexate injection for treatment of recurrent endometriotic cysts via openalex
Is there a benefit for surgery in endometrioma-associated infertility? via openalex
On the Vasculature of Ectopic Endometrium with Decidual Reaction via openalex
Pathophysiology proposed as the basis for modern management of the ovarian endometrioma via openalex
PERIVASCULAR GROWTH OF ENDOMETRIOSIS. via openalex
Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis via openalex
Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis via openalex
Pregnancy complicated by ruptured endometrioma. via openalex
Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique via openalex
Relaxin in Endometriosis via openalex
Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential via openalex
Ruptured endometrioma during pregnancy via openalex
Rupture of an ovarian endometrioma during the first trimester of pregnancy via openalex
Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery via openalex
Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety via openalex
Smooth muscle differentiation at endometrio-myometrial junction via openalex
Smooth muscle metaplasia in ovarian endometriosis via openalex
Smooth muscles are frequent components of endometriotic lesions via openalex
The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production via openalex
The impact of in situ methotrexate injection after transvaginal ultrasound-guided aspiration of ovarian endometriomas on ovarian response and reproductive outcomes during IVF-cycles via openalex
The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis via openalex
Transvaginal color Doppler sonography predicts ovarian interstitial fibrosis and microvascular injury in women with ovarian endometriotic cysts via openalex
Treatment of Endometriosis with Transvaginal Ultrasound-Guided Drainage and Recombinant Interleukin-2 Left in the Cysts: A Third Clinical Trial via openalex
Treatment of Endometriosis with Transvaginal Ultrasound-Guided Drainage under GnRH Analogues and Recombinant Interleukin-2 Left in the Cysts via openalex
Ultrasound-Guided Aspiration and Ethanol Sclerotherapy (EST) for Treatment of Cyst Recurrence in Patients after Previous Endometriosis Surgery: Analysis of Influencing Factors Using a Decision Tree via openalex
Ultrasound-guided aspiration and ethanol sclerotherapy for treating endometrial cysts via openalex
Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response via openalex
Use of Mifepristone to Treat Endometriosis: A Review of Clinical Trials and Trial-Like Studies Conducted in China via openalex
Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium via openalex
W2142973385 via openalex
W1990857541 via openalex
W1984592479 via openalex
W2097972396 via openalex
W1979519546 via openalex
W2412295907 via openalex
W2053998452 via openalex
W1967971828 via openalex
W2051768735 via openalex
W6654811829 via openalex
W6676027586 via openalex
W6717219593 via openalex
W1980447854 via openalex
W2026392453 via openalex
W2034669369 via openalex
W2036459481 via openalex
W2124856526 via openalex
W2128928486 via openalex

Cited by (13)

SciLite annotations

chemicals 9

progestin estrogen methotrexate ethanol progestin levonorgestrel danazol mifepristone ulipristal

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-05-13T22:21:07.355239+00:00
scilite: last seen: 2026-05-18T04:25:29.313245+00:00

License: CC0 · commercial use OK

[1] A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study via openalex

[2] Changes in cytokine levels of patients with ovarian endometriosis after treatment with gonadotropin-releasing hormone analogue, ultrasound-guided drainage, and intracystic recombinant interleukin-2 via openalex

[3] Clinical value of components of the plasminogen activation system in ovarian cyst fluid. via openalex

[4] Clinical value of components of the plasminogen activation system in ovarian cyst fluid. via openalex

[5] Combined ultrasonographically guided drainage and methotrexate administration for treatment of endometriotic cysts via openalex

[6] Development of a miniature, low-dose, frameless intrauterine levonorgestrel-releasing system for contraception and treatment: a review of initial clinical experience via openalex

[7] Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles via openalex

[8] Do endometriomas induce an inflammatory reaction in nearby follicles? via openalex

[9] Effectiveness of ultrasound-guided aspiration and sclerotherapy with 95% ethanol for treatment of recurrent ovarian endometriomas via openalex

[10] Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas via openalex

[11] Exploring the Relationship between Endometriomas and Infertility via openalex

[12] Expression of cadherins and CD44 isoforms in ovarian endometrial cysts via openalex

[13] Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay via openalex

[14] GnRH Analogues, Transvaginal Ultrasound-Guided Drainage and Intracystic Injection of Recombinant Interleukin-2 in the Treatment of Endometriosis via openalex

[15] High serum follistatin levels in women with ovarian endometriosis via openalex

[16] Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis via openalex

[17] Impact of ovarian endometrioma on assisted reproduction outcomes via openalex

[18] Important Initiative Roles of CD44 and Tenascin in Sampson's Theory of the Pathogenesis and Development of Endometriosis via openalex

[19] Infected endometrioma in pregnancy masquerading as acute appendicitis via openalex

[20] In situ methotrexate injection after transvaginal ultrasound-guided aspiration of ovarian endometriomas: A randomized controlled trial via openalex

[21] In situ methotrexate injection for treatment of recurrent endometriotic cysts via openalex

[22] Is there a benefit for surgery in endometrioma-associated infertility? via openalex

[23] On the Vasculature of Ectopic Endometrium with Decidual Reaction via openalex

[24] Pathophysiology proposed as the basis for modern management of the ovarian endometrioma via openalex

[25] PERIVASCULAR GROWTH OF ENDOMETRIOSIS. via openalex

[26] Plasma Urocortin Levels in the Diagnosis of Ovarian Endometriosis via openalex

[27] Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis via openalex

[28] Pregnancy complicated by ruptured endometrioma. via openalex

[29] Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique via openalex

[30] Relaxin in Endometriosis via openalex

[31] Research Resource: Gene Expression Profile for Ectopic Versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential via openalex

[32] Ruptured endometrioma during pregnancy via openalex

[33] Rupture of an ovarian endometrioma during the first trimester of pregnancy via openalex

[34] Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery via openalex

[35] Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety via openalex

[36] Smooth muscle differentiation at endometrio-myometrial junction via openalex

[37] Smooth muscle metaplasia in ovarian endometriosis via openalex

[38] Smooth muscles are frequent components of endometriotic lesions via openalex

[39] The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production via openalex

[40] The impact of in situ methotrexate injection after transvaginal ultrasound-guided aspiration of ovarian endometriomas on ovarian response and reproductive outcomes during IVF-cycles via openalex

[41] The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis via openalex

[42] Transvaginal color Doppler sonography predicts ovarian interstitial fibrosis and microvascular injury in women with ovarian endometriotic cysts via openalex

[43] Treatment of Endometriosis with Transvaginal Ultrasound-Guided Drainage and Recombinant Interleukin-2 Left in the Cysts: A Third Clinical Trial via openalex

[44] Treatment of Endometriosis with Transvaginal Ultrasound-Guided Drainage under GnRH Analogues and Recombinant Interleukin-2 Left in the Cysts via openalex

[45] Ultrasound-Guided Aspiration and Ethanol Sclerotherapy (EST) for Treatment of Cyst Recurrence in Patients after Previous Endometriosis Surgery: Analysis of Influencing Factors Using a Decision Tree via openalex

[46] Ultrasound-guided aspiration and ethanol sclerotherapy for treating endometrial cysts via openalex

[47] Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response via openalex

[48] Use of Mifepristone to Treat Endometriosis: A Review of Clinical Trials and Trial-Like Studies Conducted in China via openalex

[49] Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium via openalex

[50] W2142973385 via openalex

[51] W1990857541 via openalex

[52] W1984592479 via openalex

[53] W2097972396 via openalex

[54] W1979519546 via openalex

[55] W2412295907 via openalex

[56] W2053998452 via openalex

[57] W1967971828 via openalex

[58] W2051768735 via openalex

[59] W6654811829 via openalex

[60] W6676027586 via openalex

[61] W6717219593 via openalex

[62] W1980447854 via openalex

[63] W2026392453 via openalex

[64] W2034669369 via openalex

[65] W2036459481 via openalex

[66] W2124856526 via openalex

[67] W2128928486 via openalex