Fertility Preservation in Adolescents with Endometriosis

Endometriosis may adversely affect ovarian reserve by direct and indirect mechanisms. Adolescents with severe endometriosis may therefore be at significant risk for ovarian tissue damage over many decades, which may lead to infertility and, occasionally, premature ovarian failure. The risk for a compromised ovarian reserve is especially high in adolescents who require repeated surgical intervention and in the presence of bilateral endometriomas. Adolescents with severe endometriosis and young women likely to undergo ovarian surgical procedures should be consulted regarding the current available fertility preservation techniques (FPT). Adolescents are good candidates for ovarian tissue freezing. This procedure can often be undertaken as part of the surgery planned to treat endometriosis or to remove ovarian endometriomas. Oocyte cryopreservation could also be offered to postmenarche girls. Personalized counseling should consider age, degree of ovarian involvement, current ovarian reserve, and previous and planned surgeries for endometriosis, along with current success rates and possible risks associated with FPT. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations - AFC: - Antral follicle count - AMH: - Anti-Müllerian hormone - FPT: - Fertility preservation techniques - IVM: - In vitro maturation - OHSS: - Ovarian hyperstimulation syndrome - PCOS: - Polycystic ovary syndrome - POF: - Premature ovarian failure - TS: - Turner syndrome

Uncu G, Kasapoglu I, Ozerkan K, Seyhan A, Oral Yilmaztepe A, Ata B. Prospective assessment of the impact of endometriomas and their removal on ovarian reserve and determinants of the rate of decline in ovarian reserve. Hum Reprod. 2013;28(8):2140–5. Kitajima M, Dolmans MM, Donnez O, Masuzaki H, Soares M, Donnez J. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril. 2014;101(4):1031–7. Johnson NP, Hummelshoj L, World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod. 2013;28(6):1552–68. Muzii L, Di Tucci C, Di Feliciantonio M, Galati G, Di Donato V, Musella A, Palaia I, Panici PB. Antimüllerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis. Fertil Steril. 2018;110(5):932–940.e1. Seyhan A, Ata B, Uncu G. The impact of endometriosis and its treatment on ovarian reserve. Semin Reprod Med. 2015;33(6):422–8. Busacca M, Riparini J, Somigliana E, Oggioni G, Izzo S, Vignali M, Candiani M. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195(2):421–5. Donnez J, Dolmans MM. Fertility preservation in women. N Engl J Med. 2017;377(17):1657–65. Abir R, Ben-Aharon I, Garor R, Yaniv I, Ash S, Stemmer SM, Ben-Haroush A, Freud E, Kravarusic D, Sapir O, Fisch B. Cryopreservation of in vitro matured oocytes in addition to ovarian tissue freezing for fertility preservation in paediatric female cancer patients before and after cancer therapy. Hum Reprod. 2016;31(4):750–62. Donnez J, Dolmans MM. Transplantation of ovarian tissue. Best Pract Res Clin Obstet Gynaecol. 2014;28(8):1188–97. Meirow D, Rahanani H, Biedermann H. Ovarian tissue cryopreservation and transplantation: a realistic effective technology for fertility preservation methods. Mol Biol. 2014;1154:455–73. Jensen AK, Kristensen SG, Macklon KT, Jeppesen JV, Fedder J, Ernst E, et al. Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark. Hum Reprod. 2015;30(12):2838–45. Jensen AK, Rechnitzer C, Macklon KT, Ifversen MR, Birkebæk N, Clausen N, Sørensen K, Fedder J, Ernst E, Andersen CY. Cryopreservation of ovarian tissue for fertility preservation in a large cohort of young girls: focus on pubertal development. Hum Reprod. 2017;32(1):154–64. Elizur SE, Chian RC, Holzer HE, Gidoni Y, Tulandi T, Tan SL. Cryopreservation of oocytes in a young woman with severe and symptomatic endometriosis: a new indication for fertility preservation. Fertil Steril. 2009;91(1):293.e1–3. Barnett R, Banks N, Decherney AH. Endometriosis and fertility preservation. Clin Obstet Gynecol. 2017;60(3):517–23. Carrillo L, Seidman DS, Cittadini E, Meirow D. The role of fertility preservation in patients with endometriosis. J Assist Reprod Genet. 2016;33:317–23. Streuli I, Benard J, Hugon-Rodin J, Chapron C, Santulli P, Pluchino N. Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. Eur J Obstet Gynecol Reprod Biol. 2018;229:172–8. Somigliana E, Viganò P, Filippi F, Papaleo E, Benaglia L, Candiani M, Vercellini P. Fertility preservation in women with endometriosis: for all, for some, for none? Hum Reprod. 2015;30(6):1280–6. Shebl O, Ebner T, Sommergruber M, Sir A, Tews G. Anti-Mullerian hormone serum levels in women with endometriosis: a case–control study. Gynecol Endocrinol. 2009;25(11):713–6. Hwu YM, Wu FS-Y, Li S-H, Sun F-J, Lin M-H, Lee RK-K. The impact of endometrioma and laparoscopic cystectomy on serum anti-Mullerian hormone levels. Reprod Biol Endocrinol. 2011;9:80–4. Ercan CM, Sakinci M, Duru NK, Alanbay I, Karasahin KE, Baser I. Antimullerian hormone levels after laparoscopic endometrioma stripping surgery. Gynecol Endocrinol. 2010;26:468–72. Almog B, Shehata F, Sheizaf B, Tulandi T. Effect of different types of ovarian cyst on antral follicle count. Fertil Steril. 2010;94:2338–9. Biacchiardi CP, Piane LD, Camanni M, Deltetto F, Delpiano EM, Marchino GL, et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online. 2011;23:740–6. Suzuki T, Izumi S, Matsubayashi H, Awaji H, Yoshikata K, Makino T. Impact of ovarian endometrioma on oocytes and pregnancy outcome in vitro fertilization. Fertil Steril. 2005;83:908–13. Kumbak B, Kahraman S, Karlikaya G, Lacin S, Guney A. In vitro fertilization in normoresponder patients with endometriomas: comparison with basal simple ovarian cysts. Gynecol Obstet Invest. 2008;65(3):212–6. Opøien HK, Fedorak P, Omland AK, Abyholm T, Bjerke S, Ertzeid G, et al. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril. 2012;97(4):912–8. Cecchino GN, García-Velasco JA. Endometrioma, fertility, and assisted reproductive treatments: connecting the dots. Curr Opin Obstet Gynecol. 2018;30(4):223–8. Patrizio P, Albertini D. Old is bad, young is good, but what about very young? Oocytes obtained from pre-pubertal ovarian tissue of very young patients are incapable of in vitro maturation. Fertil Steril. 2019;112(2):239–40. Benagiano G, Bianchi P, Brosens I. Ovarian endometriomas in adolescents often represent active angiogenic disease requiring early diagnosis and careful management. Minerva Ginecol. 2017;69(1):100–7. Tsolakidis D, Pados G, Vavilis D, Athanatos D, Tsalikis T, Giannakou A, et al. The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: a prospective randomized study. Fertil Steril. 2010;94:71–7. Celik HG, Dogan E, Okyay E, Ulukus C, Saatli B, Uysal S, et al. Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimullerian hormone levels. Fertil Steril. 2012;97:1472–8. Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, et al. The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality and severity of endometriosis. Hum Reprod. 2011;26(4):904–10. Var T, Batioglu S, Tonguc E, Kahyaoglu I. The effect of laparoscopic ovarian cystectomy versus coagulation in bilateral endometriomas on ovarian reserve as determined by antral follicle count and ovarian volume: a prospective randomized study. Fertil Steril. 2011;95:2247–50. Kwon SK, Kim SH, Yun SC, Kim DY, Chae HD, Kim CH, Kang BM. Decline of serum antimüllerian hormone levels after laparoscopic ovarian cystectomy in endometrioma and other benign cysts: a prospective cohort study. Fertil Steril. 2014;101(2):435–41. Younis JS, Shapso N, Fleming R, Ben-Shlomo I, Izhaki I. Impact of unilateral versus bilateral ovarian endometriotic cystectomy on ovarian reserve: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(3):375–91. Goodman LR, Goldberg JM, Flyckt RL, Gupta M, Harwalker J, Falcone T. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Am J Obstet Gynecol. 2016;215(5):589.e1–6. Santulli P, Lamau MC, Marcellin L, Gayet V, Marzouk P, Borghese B, Lafay Pillet MC, Chapron C. Endometriosis-related infertility: ovarian endometrioma per se is not associated with presentation for infertility. Hum Reprod. 2016;31(8):1765–75. Benagiano G, Petraglia F, Gordts S, Brosens I. A new approach to the management of ovarian endometrioma to prevent tissue damage and recurrence. Reprod Biomed Online. 2016;32(6):556–62. Kasapoglu I, Ata B, Uyaniklar O, Seyhan A, Orhan A, Yildiz Oguz S, Uncu G. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril. 2018;110(1):122–7. Sarıdoğan E. Adolescent endometriosis. Eur J Obstet Gynecol Reprod Biol. 2017;209:46–9. Vitek W, Sun F, Baker VL, Styer AK, Christianson MS, Stern JE, et al. Lower anti-Mullerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity. Am J Obstet Gynecol. 2019;S0002-9378(19):31212–8. Amorim CA, Leonel ECR, Afifi Y, Coomarasamy A, Fishel S. Cryostorage and retransplantation of ovarian tissue as an infertility treatment. Best Pract Res Clin Endocrinol Metab. 2019;33(1):89–102. Jadoul P, Dolmans MM, Donnez J. Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update. 2010;16:617e30. Oktay K, Bedoschi G. Fertility preservation in girls with Turner syndrome: limitations, current success and future prospects. Fertil Steril. 2019;111(6):1124–6. Mamsen LS, Charkiewicz K, Anderson RA, Telfer EE, McLaughlin M, Kelsey TW, et al. Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation. Fertil Steril. 2019;111:1217–25. Schleedoorn MJ, van der Velden AAEM, Braat DDM, Peek R, Fleischer K. To freeze or not to freeze? An update on fertility preservation in females with turner syndrome. Pediatr Endocrinol Rev. 2019;16(3):369–82. Cobo A, García-Velasco JA, Coello A, Domingo J, Pellicer A, Remohí J. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril. 2016;105(3):755–764.e8. Cobo A, García-Velasco J, Domingo J, Pellicer A, Remohí J. Elective and Onco-fertility preservation: factors related to IVF outcomes. Hum Reprod. 2018;33(12):2222–31. Grynberg M, El Hachem H, de Bantel A, Benard J, le Parco S, Fanchin R. In vitro maturation of oocytes: uncommon indications. Fertil Steril. 2013;99(5):1182–8. Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019;365(6460):1466–9. Gruhn JR, Kristensen SG, Andersen CY, Hoffmann ER. In vitro maturation and culture of human oocytes. Methods Mol Biol. 1818;2018:23–30. Karavania G, Schachter-Safraia N, Revela A, Mordecha-Daniela T, Bauama D, Imbara T. In vitro maturation rates in young pre-menarche patients. Fertil Steril. 2019;112(2):315–22. Patrizio P, Albertinic D. Old is bad, young is good but what about very young? Oocytes obtained from pre-pubertal ovarian tissue of very young patients are incapable of in vitro maturation. Fertil Steril. 2019;112:239–40. Donnez J, Dolmans MM, Pellicer A, et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril. 2013;99:1503–13. Meirow D, Ra’anani H, Shapira M, et al. Transplantations of frozen-thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria. Fertil Steril. 2016;106:467–74. Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann MW, et al. Live birth after ovarian tissue auto-transplantation following overnight transportation before cryopreservation. Fertil Steril. 2012;97(2):387–90. Conflict of Interest Statement There are no conflicts of interest or industrial affiliations. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Seidman, D.S. (2020). Fertility Preservation in Adolescents with Endometriosis. In: Nezhat, C.H. (eds) Endometriosis in Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-52984-0_22 Download citation DOI: https://doi.org/10.1007/978-3-030-52984-0_22 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-52983-3 Online ISBN: 978-3-030-52984-0 eBook Packages: MedicineMedicine (R0)