In vitro fertilization is a successful treatment in endometriosis-associated infertility

Hans Kristian Opøien, Opøien HK, Péter Fedorcsák, Peter Fedorcsak, Anne Katerine Omland, Omland AK, Thomas Åbyholm, Abyholm T, Thomas Abyholm, Sverre Bjercke, Bjercke S, Ertzeid G, Gudvor Ertzeid, Oldereid N, Nan Birgitte Oldereid, Nan Oldereid, Jan Roar Mellembakken, Tanbo T, Tom Tanbo
Fertility and sterility · 2012 · vol. 97(4) , pp. 912–918 · doi:10.1016/j.fertnstert.2012.01.112 · PMID:22341637 · W2061829891
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In vitro fertilization effectively treats infertility associated with endometriosis.

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Abstract

ObjectiveTo assess success rates of IVF and intracytoplasmic sperm injection in women with various stages of endometriosis.DesignRetrospective cohort study.SettingReproductive medicine unit in a university hospital.Patient(s)Infertile women (n = 2,245) with various stages of endometriosis or tubal factor infertility.Intervention(s)IVF or intracytoplasmic sperm injection.Main outcome measure(s)Dose of FSH, number of oocytes retrieved, fertilization rate, implantation rate, pregnancy rate (PR), live birth/ongoing PR.Result(s)Women with endometriosis had similar pregnancy and live birth/ongoing PR as did women with tubal factor infertility, but the American Society for Reproductive Medicine (ASRM) stage I and II endometriosis patients had a lower fertilization rate, and stage III and IV patients required more FSH and had fewer oocytes retrieved. Splitting the stage III and IV groups into patients with and without endometriomas showed that the endometrioma group required more FSH and had a significantly lower pregnancy and live birth/ongoing PR.Conclusion(s)With the exception of patients with endometrioma, infertile women with various stages of endometriosis have the same success rates with IVF and intracytoplasmic sperm injection as patients with tubal factor. This contrasts with the systematic review on which the European Society of Human Reproduction and Embryology bases its recommendations.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fallopian Tube Diseases Fertilization in Vitro Infertility, Female Sperm Injections, Intracytoplasmic Adult Analysis of Variance Chi-Square Distribution Embryo Transfer Endometriosis Fallopian Tube Diseases Female Fertility Agents, Female Fertility Agents, Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Infertility, Female Infertility, Female Infertility, Female

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