Effect of embryo cryopreservation before surgery on clinical outcomes in IVF patients with endometrioma

Nozomi Takahashi, Yuma Kawahara, Y. KAWAHARA, Miyuki Harada, Tomoko Makabe, Gentaro Izumi, Osamu Wada‐Hiraike, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Reproductive medicine and biology · 2025 · vol. 24(1) , pp. e12654 · doi:10.1002/rmb2.12654 · PMID:40336970 · W4410178099
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Embryo cryopreservation before surgery in IVF patients with endometrioma improved ongoing pregnancy rates and reduced abortion rates compared to immediate embryo transfer.

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Abstract

Purpose: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma. Methods: This retrospective study included patients aged 28-42 years with endometrioma who underwent oocyte retrieval at our hospital from 2019 to 2022. Seventeen patients who underwent ECBS and 43 patients who underwent embryo transfer (ET) without surgery were included. Patient characteristics, reproductive outcomes, and obstetric outcomes were compared between the groups. Results: Maximum cyst size was significantly larger in the ECBS group than in the control group. The abortion rate per pregnancy was significantly lower (0% vs. 35.5%) in the ECBS group than in the control group. The ongoing pregnancy rate per case was significantly higher in the ECBS group than in the control group (88.2% vs. 58.1%), while the time to ongoing pregnancy was similar. Among patients in the ECBS group who experienced live births, 84.6% became pregnant following three or fewer ET attempts. Multivariate analysis revealed that ECBS was the only factor associated with ongoing pregnancy. The rates of perinatal complications are comparable between the groups. Conclusions: ECBS is an effective method to improve reproductive outcomes in IVF patients with endometrioma without prolonging the time to pregnancy.

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Outcome instruments

rASRM

Condition tags

endometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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