Reproductive medicine and biology

PurposeTo identify the specific risk factors associated with unexplained infertility (UI) among infertile couples.MethodsWe conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed t…

BACKGROUND: Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…

PurposeTo evaluate the association between hysteroscopic treatment of cesarean scar disorder (CSDi), clinical improvement, and changes in the endometrial microbiome, as this remains unclear.MethodsThis prospective observational study includ…

BackgroundThyroid autoimmunity (TAI) is prevalent among women of reproductive age and has been associated with impaired fertility; however, its effects on ovarian reserve and infertility treatment outcomes remain controversial.MethodsA narr…

This paper critically evaluates Sekiguchi et al.'s study of vaginal progesterone dose, serum progesterone thresholds, and reproductive outcomes in hormone replacement therapy frozen embryo transfer (HRT-FET) cycles. The study conflates desc…

[This corrects the article DOI: 10.1002/rmb2.70048.].

BackgroundWith the increase in the number of patients with infertility, the number of patients requiring in vitro fertilization and embryo transfer (IVF-ET) is also increasing. No established method exists for predicting pregnancy rates und…

PurposeTo assess whether autoimmune thyroiditis is associated with obstetric, perinatal, and fetal complications in a nationally representative population of pregnant women.MethodsThis retrospective study utilized data from the U.S. Nationw…

PURPOSE: This case-control study investigated whether ovarian endometriosis is associated with altered estrogen metabolism and gut or urogenital microbiota by analyzing enzyme activity, bacterial composition, and variations of estrogen meta…

BackgroundRecurrent implantation failure (RIF) is an infertility condition in which uterine factors remain difficult to diagnose and treat. Recent studies implicate the endometrial microbiome in implantation.MethodsThis clinically oriented …

PURPOSE: To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen. METHODS: Thirty-two neonatal mice were randomly assigned to 2 groups:…

PurposeTo determine the prevalence and clinical significance of arcuate uterus among infertile women using three-dimensional transvaginal ultrasound (3D-TVUS).MethodsThis retrospective cohort included 327 women evaluated for infertility bet…

PURPOSE: Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppres…

BACKGROUND: Endometriosis is increasingly recognized as a disorder of impaired reproductive immune tolerance rather than solely an endocrine disease. Although previous studies have reported inconsistent findings regarding the number of regu…

PurposeThis study investigated whether perinatal complications in assisted reproductive technology are attributable to embryo cryopreservation or the specific endometrial preparation method, comparing Fresh Embryo Transfer (Fresh ET), Natur…

PurposeThis study examined whether the incidence of retained products of conception (RPOC) differs between hormone replacement cycles (HRC) and natural ovulation cycles (NC) in frozen-thawed embryo transfer (FET) pregnancies.MethodsWe retro…

PurposeThis study aimed to develop international expert consensus statements on chronic endometritis (CE) through a comprehensive literature review of existing evidence and a modified Delphi approach.MethodsTen panelists of the Japan Societ…

PURPOSE: In women with unilateral endometriosis, how do ovarian endometriomas and their inflammatory content affect oocyte and embryo quality in affected versus healthy ovaries, and what is the impact on ART outcomes? METHODS: This study, …

PurposeTo evaluate the role of optimizing the maternal microbiome in improving pregnancy outcomes, focusing on preconception and early gestation, and to propose practical diagnostic and preventive strategies, particularly in low- and middle…

PurposeThis study examined whether the application of public insurance on assisted reproductive technology in Japan was associated with changes in the incidence of multiple blastocyst transfer (MBT) and subsequent multiple pregnancies (MP).…

PURPOSE: To clarify the efficacy and safety of the estetrol 15 mg/drospirenone 3 mg combination among Japanese women with adenomyosis by post hoc analyses of a previous randomized clinical study. METHODS: Post hoc analyses were performed u…

PurposeTo estimate the prevalence and correlates of low serum 25-hydroxyvitamin D [25(OH)D] among women attending infertility clinics in Japan.MethodsWe conducted a multicenter cross-sectional study of 17 261 women with measured 25(OH)D. De…

Research questionHow does follitropin delta administered with an individualized dose based on body weight and AMH perform in daily practice, and is this comparable to results from a randomized phase III clinical trial in terms of ovarian re…

PurposeTo study whether subchorionic hematoma (SCH) location and size in early pregnancy affect placenta accreta spectrum (PAS) risk in hormone replacement cycles (HRC).MethodsRetrospective cohort study of 685 singleton live births followin…

PurposeRecurrent implantation failure (RIF) is linked to immune dysregulation. Although tacrolimus has shown clinical benefits in RIF, its immunological mechanisms remain unclear. We assessed its effects on peripheral blood NK cell subsets …