Effects of Different Stages of Endometriosis on the Outcome of In Vitro Fertilization

Al-Fadhli R, Raedah Al-Fadhli, Simon M Kelly, Kelly SM, S. Kelly, Tulandi T, Togas Tulandi, Lin Tan S, Seang Lin Tan
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2006 · vol. 28(10) , pp. 888–891 · doi:10.1016/s1701-2163(16)32285-x · PMID:17140505 · W2152175589
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This study examined how different stages of endometriosis influence the success rates of in vitro fertilization procedures.

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Abstract

ObjectiveThis study was undertaken to evaluate the effects of different stages of endometriosis on the outcome of treatment in an in vitro fertilization (IVF) program.MethodsThis was a retrospective, matched case-control study in an academic tertiary referral centre. The study group consisted of 87 women with laparoscopically diagnosed endometriosis, and the control group consisted of 87 age-matched women undergoing IVF for different reasons. The primary outcomes were duration of stimulation, total gonadotropin dose requirement, peak serum estradiol level, total number of oocytes retrieved, fertilization rate, embryo quality, implantation rate, and clinical pregnancy rate. The effect of obliteration of the cul-de-sac by endometriosis was also evaluated.ResultsWomen with endometriosis required significantly higher gonadotropin doses than women in the control group (P < 0.01). The fertilization rate was significantly lower for women with endometriosis (P < 0.05), although there was no difference in embryo quality or in the number of embryos transferred. In patients with an obliterated cul-de-sac, fewer oocytes were retrieved than in patients in the control group (P < 0.01).ConclusionThe presence of endometriosis, including stages III and IV, does not affect IVF outcome. However, women with endometriosis require more gonadotropin stimulation than those with no endometriosis. Women with an obliterated cul-de-sac have fewer oocytes retrieved than women without obliteration.

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Condition tags

endometriosis

MeSH descriptors

Embryo Implantation Endometriosis Fertilization in Vitro Follicle Stimulating Hormone Outcome Assessment, Health Care Adult Case-Control Studies Embryo Implantation Embryo Transfer Endometriosis Female Follicle Stimulating Hormone Humans Oocytes Oocytes Pregnancy Pregnancy Rate Retrospective Studies

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