Endometriosis: a stage by stage analysis—the role of in vitro fertilization

F Olivennes, Dov Feldberg, D Feldberg, H C Liu, Hung-Ching Liu, Jacques Cohen, J Cohen, F Moy, Fred Moy, Z Rosenwaks, Zev Rosenwaks
Fertility and Sterility · 1995 · vol. 64(2) , pp. 392–398 · doi:10.1016/s0015-0282(16)57740-1 · PMID:7615119 · W2224192272
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This retrospective study of 214 endometriosis patients undergoing IVF found no differences in pregnancy outcomes compared to a control group or by endometriosis stage, though GnRH analog down-regulation increased pregnancy rates.

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Abstract

OBJECTIVE: To investigate the impact of endometriosis stage on IVF. PATIENTS: A retrospective study of 214 patients diagnosed with endometriosis who underwent 360 cycles of IVF at The New York Hospital-Cornell Medical Center. Meanwhile, 111 pure mechanical (tubal) infertility patients treated in 160 cycles at the same time were designated as the control group for comparison. MAIN OUTCOME MEASURES: Patient's hormone and semen profiles, hormonal response and outcome to stimulation, as well as the outcome of pregnancy, abortion, and delivery rate were analyzed. RESULTS: No differences in the pregnancy outcome between the endometriosis and control groups were noted when compared among the subgroups of pure endometriosis, endometriosis plus tubal factor, endometriosis plus others (primarily endometriosis plus male factor), and control. Comparing the outcomes in pure endometriosis cases by staging, we could not find any discrepancies in terms of pregnancy rates (PRs) according to the severity of the disease. The addition of GnRH analogur down-regulation to gonadotropin stimulation resulted in an increase in PR. A relatively high delivery rate (38.9% per cycle, 41.9% per retrieval, and 43.2% per transfer) was achieved when the pure endometriosis patients were treated with concomitant leuprolide acetate down-regulation and gonadotropin. CONCLUSION: We have observed that pregnancy outcome in patients with endometriosis was not different than the outcome for patients with mechanical (tubal) infertility. There were no differences in PRs by stage of endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Adult Endometriosis Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Leuprolide Leuprolide Menotropins Menotropins Pregnancy Pregnancy Outcome Retrospective Studies

Citation neighborhood

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Cited by (50)

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