Surgical Preparation of the Patient for In Vitro Fertilization

In: Infertility and Assisted Reproduction · 2008 · pp. 361–370 · doi:10.1017/cbo9780511547287.042 · W2491314118
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This paper reviews how reproductive surgery for tubal abnormalities, endometriosis, and fibroids, including salpingectomy, proximal tubal occlusion, and fibroid resection, impacts in vitro fertilization outcomes.

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This chapter reviews evidence on how reproductive surgery for tubal abnormalities, endometriosis, and uterine fibroids affects IVF cycle outcomes, focusing on whether surgery can serve as an alternative or an adjunct to assisted reproductive technologies. For distal tubal disease, the authors highlight that hydrosalpinges are associated with lower pregnancy, implantation, and delivery rates, including odds ratios from a meta-analysis comparing patients with hydrosalpinges versus tubal-factor controls without them. A major caveat noted is that at least one included investigation found no difference in pregnancy or implantation, potentially confounded by especially low implantation and ongoing pregnancy rates in the control group. Relevance to endometriosis: this chapter explicitly includes a dedicated subsection on “Endometriosis and Assisted Reproductive Technology,” situating the surgical preparation discussion in the broader context of IVF management for endometriosis.

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Abstract

This chapter reviews the evidence surrounding the effect of reproductive surgery for tubal abnormalities, endometriosis, and uterine fibroids on in vitro fertilization (IVF) cycle outcome. Salpingectomy and proximal tubal occlusion are two surgical options in the treatment of distal tubal disease. Proximal tubal occlusion represents a significantly less invasive approach, which requires less surgical dissection and operating time while still eliminating retrograde flow of hydrosalpingeal fluid into the endometrial cavity. Consideration should be given to resection of submucosal fibroids and intramural lesions that distort directly impinge upon the endometrial cavity prior to IVF. Pregnancy rates achieved with assisted reproductive technology (ART) have increased progressively in recent years, and in endometriosis, patients achieve levels of success that are significantly higher than those obtained with alternative therapies. The prolonged use of a GnRH agonist, in at least a subset of endometriosis patients, appears to improve IVF cycle outcome.
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- Frontmatter - Contents - Contributors - Foreword - Preface - Introduction - PART I PHYSIOLOGY OF REPRODUCTION - PART II INFERTILITY EVALUATION AND TREATMENT - PART III ASSISTED REPRODUCTION - 38 Medical Strategies to Improve ART Outcome: Current Evidence - 39 Surgical Preparation of the Patient for In Vitro Fertilization - 40 IVF in the Medically Complicated Patient - 41 Polycystic Ovary Syndrome and IVF - 42 Endometriosis and Assisted Reproductive Technology - 43 Evidence-Based Medicine Comparing hMG/FSH and Agonist/Antagonist and rec/Urinary hCG/LH/GnRH to Trigger Ovulation - 44 Luteal Phase Support in Assisted Reproduction - 45 Thrombophilia and Implanation Failure - 46 Intrauterine Insemination - 47 The Prediction and Management of Poor Responders in ART - 48 Oocyte Donation - 49 In Vitro Maturation of Human Oocytes - 50 Oocyte and Embryo Freezing - 51 Cryopreservation of Male Gametes - 52 The Management of Azoospermia - 53 Spermatid Injection: Current Status - 54 Optimizing Embryo Transfer - 55 Single Embryo Transfer - 56 Blastocyst Transfer - 57 Clinical Significance of Embryo Multinucleation - 58 Quality and Risk Management in the IVF Laboratory - 59 The Nurse and REI - 60 Understanding Factors That Influence the Assessment of Outcomes in Assisted Reproductive Technologies - 61 The Revolution of Assisted Reproductive Technologies: How Traditional Chinese Medicine Impacted Reproductive Outcomes in the Treatment of Infertile Couples - 62 Complications of Assisted Reproductive Technology - 63 Ectopic and Heterotopic Pregnancies Following in Vitro Fertilization - 64 The Impact of Oxidative Stress on Female Reproduction and ART: An Evidence-Based Review - 65 PGD for Chromosomal Anomalies - 66 Preimplantation Genetic Diagnosis for Single-Gene Disorders - 67 Epigenetics and ART - 68 Congenital Anomalies and Assisted Reproductive Technology - PART IV ETHICAL DILEMMAS IN FERTILITY AND ASSISTED REPRODUCTION - Index - Plate section - References from PART III - ASSISTED REPRODUCTION Published online by Cambridge University Press: 04 August 2010 Book contents - Frontmatter - Contents - Contributors - Foreword - Preface - Introduction - PART I PHYSIOLOGY OF REPRODUCTION - PART II INFERTILITY EVALUATION AND TREATMENT - PART III ASSISTED REPRODUCTION - 38 Medical Strategies to Improve ART Outcome: Current Evidence - 39 Surgical Preparation of the Patient for In Vitro Fertilization - 40 IVF in the Medically Complicated Patient - 41 Polycystic Ovary Syndrome and IVF - 42 Endometriosis and Assisted Reproductive Technology - 43 Evidence-Based Medicine Comparing hMG/FSH and Agonist/Antagonist and rec/Urinary hCG/LH/GnRH to Trigger Ovulation - 44 Luteal Phase Support in Assisted Reproduction - 45 Thrombophilia and Implanation Failure - 46 Intrauterine Insemination - 47 The Prediction and Management of Poor Responders in ART - 48 Oocyte Donation - 49 In Vitro Maturation of Human Oocytes - 50 Oocyte and Embryo Freezing - 51 Cryopreservation of Male Gametes - 52 The Management of Azoospermia - 53 Spermatid Injection: Current Status - 54 Optimizing Embryo Transfer - 55 Single Embryo Transfer - 56 Blastocyst Transfer - 57 Clinical Significance of Embryo Multinucleation - 58 Quality and Risk Management in the IVF Laboratory - 59 The Nurse and REI - 60 Understanding Factors That Influence the Assessment of Outcomes in Assisted Reproductive Technologies - 61 The Revolution of Assisted Reproductive Technologies: How Traditional Chinese Medicine Impacted Reproductive Outcomes in the Treatment of Infertile Couples - 62 Complications of Assisted Reproductive Technology - 63 Ectopic and Heterotopic Pregnancies Following in Vitro Fertilization - 64 The Impact of Oxidative Stress on Female Reproduction and ART: An Evidence-Based Review - 65 PGD for Chromosomal Anomalies - 66 Preimplantation Genetic Diagnosis for Single-Gene Disorders - 67 Epigenetics and ART - 68 Congenital Anomalies and Assisted Reproductive Technology - PART IV ETHICAL DILEMMAS IN FERTILITY AND ASSISTED REPRODUCTION - Index - Plate section - References Surgical management of tubal abnormalities, endometriosis, and uterine fibroids has traditionally been employed to enhance fertility in the absence of the assisted reproductive technologies as has been reviewed elsewhere in this text. Can these procedures be employed not only as alternatives to the assisted reproductive technologies but also as adjuncts? In this chapter, we will review the evidence surrounding the effect of reproductive surgery for these conditions on in vitro fertilization (IVF) cycle outcome. DISTAL TUBAL DISEASE IVF was originally designed to overcome infertility due to irreversible tubal disease or for those who did not wish to undergo surgical repair. A large body of literature has reported that either unilateral or bilateral hydrosalpinges may exert deleterious effects on IVF cycle outcome (1–10) (Table 39.1). Camus et al. performed a meta-analysis of nine retrospective controlled series and five published abstracts encompassing 1,004 patients with hydrosalpinges and 4,588 control patients with tubal factor infertility but without hydrosalpinges (11). Significant decreases in pregnancy, implantation, and delivery rates were appreciated in the hydrosalpinx groups (odds ratios 0.64, 0.63, and 0.58, respectively). Only one investigation included in the meta-analysis noted no difference in pregnancy or implantation rates in hydrosalpinx patients as opposed to controls (12). One confounding variable in that particular trial may be the low implantation and ongoing pregnancy rates in the control group. - Type - Chapter - Information - Infertility and Assisted Reproduction , pp. 361 - 370Publisher: Cambridge University PressPrint publication year: 2008 Does hydrosalpinx reduce the pregnancy rate after in vitro fertilization?Fertil Steril 1997;68:1022–6.CrossRefGoogle ScholarPubMed , , , , , . Low implantation rate after in-vitro fertilization in patients with hydrosalpinges diagnosed by ultrasonography. Hum Reprod 1994;9:1935–8.CrossRefGoogle ScholarPubMed , , , . Hydrosalpinx reduces in-vitro fertilization/embryo transfer pregnancy rates. 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