Endometriosis: Comparison among different ovarian stimulation regimens for assisted procreation procedures in patients with endometriosis
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This study compared ovarian stimulation regimens for endometriosis patients undergoing assisted reproduction, finding GnRHa use increased oocytes retrieved and fertilization rates compared to clomiphene citrate-HMG.
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Abstract
The objective of our study was to establish the most adequate ovarian stimulation regimen for assisted procreation in endometriotic patients. It consisted of a retrospective analysis comparing the use of the gonadotrophin-releasing hormone analogue (GnRHa) buserelin either for 3 months or for 3 weeks and continued with ovarian stimulation with human menopausal gonadotrophin (HMG), and the use of clomiphene citrate in association with HMG for in-vitro fertilization (IVF) and embryo transfer, gamete intra-Fallopian transfer (GIFT) and zygote intra-Fallopian transfer (ZIFT). A total of 145 patients with endometriosis in 174 cycles were divided into two groups according to the revised American Fertility Society staging of the disease (group A, stages 1 and 2; group B, stages 3 and 4). The use of GnRHa significantly increased the number of oocytes retrieved. GnRH analogues for 3 months gave the highest fertilization rate for groups A and B. The cleavage, pregnancy and delivery rates, although higher in the groups treated with analogues, did not reach statistical significance. A higher number of patients had an embryo transfer in the groups treated with GnRHa (P < 0.05). Treatment with GnRHa for either 3 months or for 3 weeks proved to be more efficient than clomiphene citrate-HMG for assisted procreation procedures in patients with endometriosis.
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Cited by (26)
- Endometriosis and Fertility: Where Do We Draw the Line? 2025
- Effects of pretreatment with long-acting gonadotropin-releasing hormone agonists on pregnancy outcomes in patients with minimal and mild peritoneal endometriosis: A retrospective study of 274 frozen-thawed embryo transfer cycles 2024
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Effect of Prolonged GnRH Agonist Downregulation on ICSI Outcome in Patients With Endometriomas of Less Than 5 cm: A Randomized Controlled Trial 2018
- <i>In Vitro</i> Fertilization for Endometriosis-Associated Infertility 2015
- Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies 2015
- Comparison of Ovulation Induction Protocols After Endometrioma Resection 2014
- Endometriosis and Assisted Reproductive Technologies: Maximizing Outcomes 2013
- Efficacy and safety of IVF/ICSI in patients with severe endometriosis after long-term pituitary down-regulation 2013
- Endometriosis and ART 2012
- In vitro fertilization is a successful treatment in endometriosis-associated infertility 2012
- Sterilitätstherapie bei Endometriose 2010
- Outcome of the IVF for the Patients with Endometrioma Associated Infertility 2009
- Surgical Preparation of the Patient for In Vitro Fertilization 2008
- Zur Bedeutung der Endometriose in der Reproduktionsmedizin 2007
- Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis 2007
- Is it of value to treat endometriosis prior to IVF 2006
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2004
- Ovarian stimulation for <i>in vitro</i> fertilization in patients with endometriosis 2004
- Does Endometriosis Affect the Results of In Vitro Fertilization? 2003
- Conduite à tenir en cas de kyste ovarien chez une patiente ayant une endométriose connue 2002
- Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey 2000
- Medical management of endometriosis and infertility 2000
- Chapter 7 Endometriosis-associated Infertility and New Reproductive Technologies 1999
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