Endometriosis and Fertility: Where Do We Draw the Line?

Natalie E Rivera, N Rivera, Sadikah Behbehani
Seminars in reproductive medicine · 2025 · vol. 43(03) , pp. 214–220 · doi:10.1055/s-0045-1811510 · PMID:40854538 · W4413770356
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review examines current theories on how endometriosis impacts reproductive function and discusses the latest medical, surgical, and assisted reproductive technology approaches for managing infertility in affected patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper reviews current theories and evidence on how endometriosis impairs fertility, covering both natural conception and outcomes after assisted reproductive technologies, including IVF/ICSI and the role of endometrioma and deep infiltrating disease. It synthesizes literature on medical and surgical strategies used in infertility management, while also framing the mechanisms linking endometriosis to reproductive dysfunction. A key limitation is that the paper is a narrative overview rather than presenting new primary data, reflecting the ongoing complexity and incomplete mechanistic understanding in the field. This paper is centrally about endometriosis — it focuses specifically on endometriosis-related infertility and reproductive outcomes.

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Abstract

Endometriosis affects millions of women around the world, yet it remains a complex and often misunderstood condition, with limited funding available for research. Although much about this enigmatic disease is still unknown, emerging data continue to shed light on its mechanisms, leading to improved understanding and better management options for patients. While advances have been made in understanding the symptoms and pathophysiology of endometriosis, one critical area remains underexplored: its impact on fertility. It is now well established that endometriosis can significantly impair fertility, posing additional challenges for women trying to conceive. This study explores current theories on how endometriosis affects reproductive function and highlights the latest research on both medical and surgical approaches to managing infertility in these patients. It will also examine the implications of endometriosis on natural conception as well as outcomes related to assisted reproductive technologies.

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Outcome instruments

Enzian

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Fertility Fertility Fertility Fertility Fertility Fertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

SciLite annotations

organisms 1
noordeloos 2009062

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europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
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pubmed
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License: CC0 · commercial use OK