Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis

Erol Tavmergen, Tavmergen E, Ulukus M, Murat Ulukus, Murat Ulukuş, Ege Nazan Tavmergen Goker, Goker EN, Ege Nazan Tavmergen Göker
Current opinion in obstetrics & gynecology · 2007 · vol. 19(3) , pp. 284–288 · doi:10.1097/gco.0b013e3281053a52 · PMID:17495647 · W2089828749
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Prolonged pretreatment with gonadotropin-releasing hormone analogue before IVF has been reported to improve clinical pregnancy rates in infertile women with endometriosis.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-20 · read from full text ⓘ

This review examines the association between endometriosis and infertility, highlighting that the condition is linked to reduced pregnancy and implantation rates during assisted reproductive cycles. The authors evaluate the efficacy of medical suppression prior to in vitro fertilization, noting that while general suppression may not be warranted, prolonged pretreatment with gonadotropin-releasing hormone analogues has been reported to improve clinical pregnancy outcomes. The paper concludes that infertile women with endometriosis may benefit from this specific long-term hormonal pretreatment strategy before undergoing IVF procedures. This paper is centrally about endometriosis — specifically its impact on fertility and the use of GnRH analogues as a pretreatment protocol for assisted reproduction.

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Abstract

PURPOSE OF REVIEW: To discuss the relationship between endometriosis and infertility, the impact of endometriosis on assisted reproductive techniques and also the benefits of prolonged use of gonadotropin-releasing hormone analogue before IVF in women with endometriosis. RECENT FINDINGS: The available evidence suggests that endometriosis is strongly associated with infertility. Many studies indicate lower pregnancy and implantation rates even in assisted reproductive cycles in women with endometriosis. It is well known that medical suppression of endometriosis does not appear to be warranted for endometriosis-associated infertility. Prolonged pretreatment with gonadotropin-releasing hormone analogue before IVF has been reported to improve clinical pregnancy rates in infertile women with endometriosis. SUMMARY: Based on the recently published data, infertile women with endometriosis may benefit from long-term pretreatment of gonadotropin-releasing hormone analogue prior to IVF.
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Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis - Erol Tavmergen - Murat Ulukus - Ege Nazan Tavmergen Goker Purpose of review To discuss the relationship between endometriosis and infertility, the impact of endometriosis on assisted reproductive techniques and also the benefits of prolonged use of gonadotropin-releasing hormone analogue before IVF in women with endometriosis. Recent findings The available evidence suggests that endometriosis is strongly associated with infertility. Many studies indicate lower pregnancy and implantation rates even in assisted reproductive cycles in women with endometriosis. It is well known that medical suppression of endometriosis does not appear to be warranted for endometriosis-associated infertility. Prolonged pretreatment with gonadotropin-releasing hormone analogue before IVF has been reported to improve clinical pregnancy rates in infertile women with endometriosis. Summary Based on the recently published data, infertile women with endometriosis may benefit from long-term pretreatment of gonadotropin-releasing hormone analogue prior to IVF.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Gonadotropin-Releasing Hormone Endometriosis Endometriosis Endometriosis Female Fertilization in Vitro Gonadotropin-Releasing Hormone Humans Interleukins Interleukins Time Factors Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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