Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis

Dagmar Rickes, Rickes D, Nickel I, Ingrid Nickel, Siegfried Kropf, Kropf S, Kleinstein J, Jürgen Kleinstein, J. Kleinstein
Fertility and Sterility · 2002 · vol. 78(4) , pp. 757–762 · doi:10.1016/s0015-0282(02)03338-1 · PMID:12372452 · W2044680882
article OA: closed CC0 ⤵ 104 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated whether ultralong postoperative therapy with gonadotropin-releasing hormone analogs increases pregnancy rates in patients with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo examine whether ultralong GnRH analog (GnRH-a) therapy after surgical treatment of endometriosis and before ART influences the pregnancy rate.DesignProspective, randomized, controlled study.SettingUniversity clinic for reproductive medicine and gynecologic endocrinology.Patient(s)One hundred ten patients with stage II to IV endometriosis according to ASRM criteria.Intervention(s)Fifty-five patients received GnRH-a for 6 months after surgery and subsequently underwent up to 3 cycles of ART, and 55 patients received 3 cycles of ART alone immediately after surgery.Main outcome measure(s)Clinical pregnancy rates.ResultsThe pregnancy rate per patient was higher among patients who received follow-up treatment with GnRH-a. The same results were found in patients with stage III or IV endometriosis who were undergoing IUI or IVF/ICSI.Conclusion(s)Ultralong GnRH-a therapy increases the pregnancy rate of ART in patients with severe endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Goserelin Adult Endometriosis Female Fertilization in Vitro Goserelin Goserelin Humans Insemination, Artificial, Homologous Postoperative Period Pregnancy Prospective Studies Sperm Injections, Intracytoplasmic Time Factors Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-25T06:15:30.875455+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:01.552487+00:00
License: CC0 · commercial use OK