Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis

Dagmar Rickes, Rickes D, Nickel I, Ingrid Nickel, Siegfried Kropf, Kropf S, Kleinstein J, Jürgen Kleinstein, J. Kleinstein
Fertility and sterility · 2002 · vol. 78(4) , pp. 757–762 · doi:10.1016/s0015-0282(02)03338-1 · PMID:12372452 · W2044680882
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This study investigated whether ultralong postoperative therapy with gonadotropin-releasing hormone analogs increases pregnancy rates in patients with endometriosis.

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Abstract

OBJECTIVE: To examine whether ultralong GnRH analog (GnRH-a) therapy after surgical treatment of endometriosis and before ART influences the pregnancy rate. DESIGN: Prospective, randomized, controlled study. SETTING: University clinic for reproductive medicine and gynecologic endocrinology. PATIENT(S): One hundred ten patients with stage II to IV endometriosis according to ASRM criteria. INTERVENTION(S): Fifty-five patients received GnRH-a for 6 months after surgery and subsequently underwent up to 3 cycles of ART, and 55 patients received 3 cycles of ART alone immediately after surgery. MAIN OUTCOME MEASURE(S): Clinical pregnancy rates. RESULTS: The pregnancy rate per patient was higher among patients who received follow-up treatment with GnRH-a. The same results were found in patients with stage III or IV endometriosis who were undergoing IUI or IVF/ICSI. CONCLUSION(S): Ultralong GnRH-a therapy increases the pregnancy rate of ART in patients with severe endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Goserelin Adult Adult Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Goserelin Goserelin Goserelin Humans Humans Insemination, Artificial, Homologous Insemination, Artificial, Homologous Postoperative Period Postoperative Period

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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