Inhibin A, Inhibin B and Activin A in Follicular Fluid of Infertile Women with Tubal Damage, Unexplained Infertility and Endometriosis1
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Follicular fluid inhibin A was significantly higher in women with endometriosis and correlated with follicle size, but no inhibin or activin levels correlated with oocyte quality or fertilizing capacity across the studied infertility groups.
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Abstract
PROBLEM: To measure and compare concentrations of inhibin A, inhibin B, activin A and oestradiol in the follicular fluid of women with endometriosis, tubal damage and unexplained infertility with oocyte quality and fertilising capacity. Also, to assess whether impaired follicular function in women with endometriosis might be related to altered inhibin or activin concentrations and whether this correlated. METHOD OF STUDY: Follicular fluids were collected from individual follicles during oocyte retrieval for in vitro fertilisation (IVF) in natural cycles. Inhibin A, inhibin B and activin A were measured using two-site enzyme immunoassay, and oestradiol was assayed by fluoro-immunometric method. RESULTS: Follicular fluid inhibin A levels were found to be significantly higher in women with endometriosis. Inhibin A was directly correlated with follicle size. There was no correlation between the levels of inhibin A, inhibin B, activin A and oocyte quality or fertilising capacity in the three groups of women. CONCLUSIONS: Follicular fluid concentration of inhibin A is elevated in follicles of women with endometriosis and is positively correlated with follicle maturation. However, we were unable to demonstrate any association between the follicular fluid concentrations of inhibin A, inhibin B, activin A or oestradiol and the quality and fertilisation capacity of oocytes in women with tubal damage, unexplained infertility or endometriosis.
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Cited by (16)
- Analogs of Luteinizing Hormone-Releasing Hormone in the Treatment of Endometriosis 2015
- Follicular-fluid anti-Müllerian hormone concentration is similar in patients with endometriosis compared with non-endometriotic patients 2010
- Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model 2008
- Stérilité par endométriose 2007
- Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis 2007
- Optimising in vitro fertilisation (IVF) outcome in women with endometriosis 2006
- Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility 2005
- Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and -3 in the follicular fluid of infertile patients with endometriosis 2003
- Pre‐ovulatory Granulosa Cells of Infertile Women with Endometriosis are Less Sensitive to Luteinizing Hormone 2003
- Differences in time to natural conception between women with unexplained infertility and infertile women with minor endometriosis 2003
- Reproductive disorders affecting fertility in endometriosis 2002
- New advances in the understanding of endometriosis related infertility 2002
- Endometriosis and infertility: The debate continues 2002
- Different aetiological mechanisms for unexplained and endometriosis-associated infertility cannot be inferred from unstimulated IVF cycles using HCG to induce ovulation 2002
- Reproductive disorders affecting fertility in 2001
- Endometriosis and assisted reproductive technologies: are outcomes affected? 2001
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- openalex
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