Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model

Annemiek Nap, Annemiek W Nap, Nap AW, Groothuis PG, Patrick G Groothuis, Chamindie Punyadeera, Ludger Klein‐Hitpaß, Klein-Hitpass L, Ludger Klein-Hitpass, Rik Kamps, Kamps R, Delvoux B, Bert Delvoux, Gerard A J Dunselman, Dunselman GA
Contraception · 2008 · vol. 78(3) , pp. 257–265 · doi:10.1016/j.contraception.2008.05.003 · PMID:18692618 · W2006952872
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Oral contraceptives administered to the chicken chorioallantoic membrane model prevented the development of induced endometriosis.

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Abstract

BackgroundFundamental and genetic differences between women in the endometrium may cause some to develop endometriosis, whereas others do not. Oral contraceptives (OC) may have an effect on the endometrium, rendering the development of endometriosis less likely.Study designEndometrium from women using OC (OCE) and menstrual endometrium (ME) from normal cycling women were transplanted onto the chicken chorioallantoic membrane (CAM), and endometriosis-like lesion formation was evaluated. Microarray gene expression profiling was performed to identify differentially expressed genes in the endometrium from these groups. Microarray data were validated by real-time PCR.ResultsLess endometriosis-like lesions were formed after transplantation of OCE than after transplantation of ME (p<.05). Most of the differentially expressed genes belong to the TGFbeta superfamily. Real-time PCR validation revealed that inhibin betaA (INHBA) expression was significantly decreased in OCE as compared to ME.ConclusionOC use affects the characteristics of endometrium, rendering it less potent to develop into endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral, Hormonal Endometriosis Endometrium Adult Animals Case-Control Studies Chickens Chorioallantoic Membrane Contraceptives, Oral, Hormonal Endometriosis Endometrium Endometrium Female Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis Tissue Culture Techniques Young Adult

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