Pre‐ovulatory Granulosa Cells of Infertile Women with Endometriosis are Less Sensitive to Luteinizing Hormone

Cahill DJ, David J Cahill, Christopher R. Harlow, Harlow CR, Peter G. Wardle, Wardle PG
American journal of reproductive immunology (New York, N.Y. : 1989) · 2003 · vol. 49(2) , pp. 66–69 · doi:10.1034/j.1600-0897.2003.01156.x · PMID:12765343 · W2069863680
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Granulosa cells from pre-ovulatory follicles of infertile women with minor endometriosis exhibited reduced sensitivity to luteinizing hormone stimulation compared to controls.

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Abstract

PROBLEM: Reduced fertilization rates in women with minor endometriosis may be the result of direct effects on the ovary or to primary dysfunction within the hypothalamic-pituitary-ovarian axis. This controlled study was designed to examine the steroidogenic potential of luteinized granulosa cells in women with minor endometriosis. METHOD OF STUDY: Granulosa cells were harvested at oocyte recovery and incubated for 3 hr in increasing concentrations of luteinizing hormone (LH). The dissociation constant for added concentrations of LH was computed (as Km LH) and the results were compared between women with endometriosis and controls. RESULTS: Women with minor endometriosis had a higher dissociation constant than women with tubal damage [Km 0.98 (0.58-9.24) versus 0.33 (0.28-0.72) ng/mL, P = 0.019], indicating reduced sensitivity to LH. CONCLUSIONS: In women with endometriosis, granulosa cells were less sensitive to LH stimulation. This provides further evidence for primary ovarian dysfunction as a significant contributory cause of the associated subfertility.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Granulosa Cells Infertility, Female Luteinizing Hormone Endometriosis Female Granulosa Cells Humans Infertility, Female Kinetics Luteinizing Hormone

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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