Ovarian Dysfunction in Endometriosis-Associated and Unexplained Infertility

David J Cahill, D J Cahill, Peter G. Wardle, P G Wardle, L A Maile, Christopher R. Harlow, C R Harlow, M G Hull, M.G.R. Hull
Journal of assisted reproduction and genetics · 1997 · vol. 14(10) , pp. 554–557 · doi:10.1023/a:1022568331845 · PMID:9447453 · PMC3454742 · W1499501313
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis and unexplained infertility were found to have reduced LH concentrations in follicular fluid compared to tubal damage, with endometriosis also showing a reduced fertilization rate.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study compared follicular maturation, endocrine measures, and fertilization outcomes in natural, unstimulated cycles across three groups: 18 women with minor endometriosis (41 cycles), 15 with unexplained infertility (31 cycles), and 34 with tubal damage (88 cycles). It found that the endometriosis group had a longer follicular phase and that both the endometriosis and unexplained infertility groups had reduced LH concentrations in follicular fluid compared with tubal damage. Despite these endocrine similarities, endometriosis was associated with a significantly lower fertilization rate (46%) than either unexplained infertility (65%) or tubal damage (69%). The authors conclude that the findings support continuing evidence of ovulatory dysfunction affecting fertilization in minor endometriosis, while noting the study is limited to women undergoing cycles “totally unperturbed by exogenous gonadotrophins.” This paper is centrally about endometriosis — it examines ovarian dysfunction and reduced fertilization rates in endometriosis-associated infertility during natural cycles.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Ovary Adult Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Fertilization in Vitro Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Follicular Fluid Follicular Fluid Humans Infertility, Female Luteinizing Hormone Luteinizing Hormone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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