Development of peritoneal endometriosis: Characterisation of immune environment in peritoneal endometriotic lesions

Burcu Ersoy
2015 · W1795799710
dissertation OA: green CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study characterized immune cells in peritoneal endometriotic lesions and found differences in their densities and correlations, suggesting immune cell recruitment may promote lesion growth.

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Abstract

Endometriosis is an inflammatory condition in which the immune system is thought to play a fundamental role in establishment and progression. Within peritoneal endometriotic lesions there is evidence of increased immune cell recruitment and activation. However, it is still unclear how the immune environment relates to peritoneal endometriotic lesion development. Therefore, the main aim of this project was to investigate peritoneal endometriotic lesion development by characterising the immune environment by macroscopic appearance (red, black and white scarred). Peritoneal endometriotic lesions were prospectively collected and immunohistochemically stained to identify T cells, B cells, macrophages and dendritic cells. Immune cells were present in both the endometriotic stroma and lesion-surrounding tissue. Additionally, there were some differences in immune cell population densities between stroma and surrounding tissue. Also a number of correlations were found between the densities of different immune cell populations in both tissue types, indicating relationships and interactions between cell types. The density of immune cells in and around peritoneal endometriotic lesions was not correlated with lesion appearance. The recruitment of immune cells to tissue within and around peritoneal endometriotic lesions is likely an attempt to attack the lesion. However, products released by these cells may in fact promote processes such as angiogenesis and fibrosis and thereby lesion growth and persistence. The findings from this thesis have implications for understanding of endometriosis pathogenesis, and also potentially for development of novel treatment approaches.

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endometriosis

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